The Faster Cooling Rate and More Stable Cooling Process in Endovascular Cooling Shorten Patients’ Time in ICU

This study conducted a meta-analysis to assess the effectiveness, stability, and safety of mild therapeutic hypothermia (TH) induced by endovascular cooling (EC) and surface cooling (SC) and its effect on ICU, survival rate,... read more

The Faster Cooling Rate and More Stable Cooling Process in Endovascular Cooling Shorten Patients’ Time in ICU

Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes

The severity of cardiogenic shock following asystolic cardiac arrest is dependent on the length of cardiac arrest prior to cardiopulmonary resuscitation and is mediated by myocardial stunning resulting from mitochondrial... read more

Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes

Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence... read more

Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

Epinephrine During Resuscitation of Traumatic Cardiac Arrest and Increased Mortality

Epinephrine administered during in-hospital resuscitation was associated with lower 7-day survival rate in patients with out-of-hospital cardiac arrest (OHCA) following trauma. While we examined the outcomes of selected... read more

Epinephrine During Resuscitation of Traumatic Cardiac Arrest and Increased Mortality

Neuroprognostication Practices in Postcardiac Arrest Patients

Neuroprognostic approaches to hypoxic-ischemic encephalopathy vary among physicians and are often not consistent with current guidelines. The overall inconsistency in approaches and deviation from evidence-based recommendations... read more

Neuroprognostication Practices in Postcardiac Arrest Patients

Association Between Hypothermia/Ischemia Ratio and Functional Outcome

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Association Between Hypothermia/Ischemia Ratio and Functional Outcome

Temporal Utilization Trends in Prehospital Mechanical CPR Devices

Chest compressions have remained one of the most visible and effective components of prehospital resuscitation, dating back to the inception of modern emergency medical services (EMS). Although the idea and technique... read more

Temporal Utilization Trends in Prehospital Mechanical CPR Devices

Intravenous Fluid Therapy in Critically Ill Adults

Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived mainly from academically... read more

Intravenous Fluid Therapy in Critically Ill Adults

Could the Furosemide Stress Test Clarify Resuscitative Goals?

Imagine that you admit a patient with septic shock. You resuscitate the patient as best you can with inopressors, fluids, and antibiotics. An adequate blood pressure is achieved. A reasonable amount of fluid is administered.... read more

Could the Furosemide Stress Test Clarify Resuscitative Goals?

Ventilator Management: Advanced Concepts In Critical Care

Mechanical ventilation is a broad subject that encompasses many factors that must be considered while providing overall resuscitation. It is not as easy as just entering in a rate and tidal volume and pushing start. Critical... read more

Ventilator Management: Advanced Concepts In Critical Care

If we don’t start looking after our doctors there will be no one to care for our patients

"Would you choose medicine again?" I look into the eager faces of the sixth-formers I've been asked to speak to. Not for the first time, I hesitate before I answer. I love my job – it's a great privilege to be a Registrar... read more

If we don’t start looking after our doctors there will be no one to care for our patients

Prognostication with Point-of-Care Echocardiography During Cardiac Arrest (ALS)

This topic was prioritized by the ALS Task Force based on the high prevalence of point-of-care echocardiography during cardiac arrest without recognizing the potential pitfalls for misinterpretation as an adjunct prognostic... read more

Prognostication with Point-of-Care Echocardiography During Cardiac Arrest (ALS)

Enteral Nutrition Can Be Given to Patients on Vasopressors

Most all recent studies show Enteral Nutrition (EN) can be delivered safely to patients on vasopressors. In fact, many studies show an outcome benefit of early EN (EEN) in ICU patients who are receiving vasopressors. It... read more

Enteral Nutrition Can Be Given to Patients on Vasopressors

Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock

Favorable changes in physiologic and biochemical variables and norepinephrine dependency were observed after IHD in patients with septic shock complicated by metabolic acidosis during resuscitation. Further studies are needed... read more

Intermittent Hemodialysis for Managing Metabolic Acidosis During Resuscitation of Septic Shock

A 10-Year Longitudinal Analysis of Protocol-Based Sepsis Management

This 10-year single-center retrospective cohort showed that the use of PB management of severe sepsis and septic shock was associated with a decreased hospital mortality for patients. This mortality benefit was preserved... read more

A 10-Year Longitudinal Analysis of Protocol-Based Sepsis Management

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

The Oxygen Revolution: The Definitive Treatment of Traumatic Brain Injury (TBI) & Other Disorders

Hyperbaric oxygen therapy (HBOT) is based on a simple idea—that oxygen can be used therapeutically for a wide range of conditions where tissues have been damaged by oxygen deprivation. Inspiring and informative, The... read more

The Oxygen Revolution: The Definitive Treatment of Traumatic Brain Injury (TBI) & Other Disorders

Vasopressin for Acute Hemorrhage?

Vasoactive medications are one of the pillars of management of shock in Emergency Departments. Inopressors, namely Norepinephrine and Epinephrine, are the two most commonly used pressors in US Emergency Departments, used... read more

Vasopressin for Acute Hemorrhage?

Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury

Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers... read more

Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury

The Protective Effects of Regional Hypothermia on Injured Limbs Combined with Hemorrhagic-shock & Tourniquet

The aim of this study is to investigate the protective effects of regional hypothermia (RH) on rabbits' limbs injured by a steel-ball combined with hemorrhagic-shock, and then employed tourniquet over-time, tried to identify... read more

The Protective Effects of Regional Hypothermia on Injured Limbs Combined with Hemorrhagic-shock & Tourniquet

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

In this multicenter cohort, ventilation rates exceeding guidelines were common. Among the range of rates delivered, higher rates were associated with improved survival to hospital discharge. Arterial blood pressure and... read more

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

Critical Care Doctors Placed Humans in Suspended Animation For The First Time

Critical care doctors have placed humans in suspended animation for the first time, as part of a trial in the US that aims to make it possible to fix traumatic injuries that would otherwise cause death. Samuel Tisherman,... read more

Critical Care Doctors Placed Humans in Suspended Animation For The First Time