Tag: study
Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C
Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized... read more
Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients
Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more
Plasma Exchange in the ICU
In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more
Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality
In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may... read more
Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients
The Care Step Pathway (CSP) described in this article was developed to increase awareness of the potential association of SARS-CoV-2 infection with invasive fungal infections, particularly pulmonary aspergillosis. The... read more
Dexmedetomidine vs. Propofol Sedation in Critically Ill Adults Requiring Mechanical Ventilation
Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients. It also significantly... read more
Myocarditis After COVID‐19 mRNA Vaccination in Australia
Myocarditis in adolescents and young adults following the administration of coronavirus disease 2019 (COVID‐19) mRNA vaccines has been reported. Vaccination of 12–16‐year‐old adolescents with Comirnaty (tozinameran,... read more
Improving Outcomes in Patients with Difficult Airways
Evidence indicates that the airway community has successfully conquered the anatomically difficult airway, as these patients are managed safely with a low incidence of morbidity and mortality. In contrast, the literature... read more
The Effect of ICU Diaries on PTSD, Anxiety, and Depression
Providing an ICU diary to patients admitted to the ICU reduced the rate of posttraumatic stress disorder (PTSD) symptoms compared with usual care. We included 7 RCTs. Patients who received a diary during the ICU admission... read more
Advanced Bleeding Control in Combat Casualty Care
Consensus was reached on the contents of a standard bleeding control toolbox, where it should be available, providers and training requirements, international registries and guidelines, and potential indications for REBOA... read more
Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness
Whereas etomidate causes adrenal insufficiency, it was not shown to increase mortality in many analyzed here in ICU settings. However, etomidate associated relative mortality rates increased progressively and correlated with... read more
Pulmonary Aeration and Posterior Collapse Assessed by Electrical Impedance Tomography in Healthy Children
The aim of this study was to evaluate the changes in the lung aeration estimated by electrical impedance tomography as the end-expiratory lung impedance after anesthesia induction in pediatric patients. This was a prospective,... read more
Endoscopic Sleeve Gastroplasty for Treatment of Obesity
Endoscopic sleeve gastroplasty (ESG) is a safe intervention that resulted in significant weight loss, maintained at 104 weeks, with important improvements in metabolic comorbidities. ESG should be considered as a synergistic... read more
High Rate of PICS Among SICU Survivors
Through the successful implementation of a multidisciplinary critical care outpatient clinic (CCOC), this study identifies an exorbitant rate of postintensive care syndrome (PICS) among surgical intensive care unit (SICU)... read more
Baricitinib in COVID-19 Patients
In patients hospitalized with COVID-19, baricitinib significantly reduced the risk of death but the size of benefit was somewhat smaller than that suggested by previous trials. The total randomized evidence to date suggests... read more
Developing a Decision Instrument to Guide Abdominal-pelvic Imaging of Blunt Trauma Patients
Although computed tomography (CT) of the abdomen and pelvis (A/P) can provide crucial information for managing blunt trauma patients, liberal and indiscriminant imaging is expensive, can delay critical interventions, and... read more
Bleeding and Thrombotic Events in Patients with Severe COVID‑19 on ECMO
In a nationwide cohort of COVID‑19 patients supported by extracorporeal membrane oxygenation (ECMO), bleeding incidence was high and associated with mortality. Intracranial hemorrhage incidence was higher than reported... read more
Nasotracheal Intubation on Postoperative Neonates with Congenital Heart Disease
Nasotracheal intubation (NTI) is feasible and safe in neonatal cardiac surgery. System-level engagement with stakeholders is necessary to change clinical practice. NTI facilitates early SLP evaluation and treatment and significantly... read more
Postoperative Sepsis Infection Can Be Identified Using Gene Expression Signatures
Host biomarker signatures may be able to identify postoperative infection or sepsis up to three days in advance of clinical recognition. If validated in future studies, these signatures offer potential diagnostic utility... read more
Evaluation of an Advanced Critical Care Echocardiography Program
Trainees perceived lack of time and limited access to supervision as major barriers to course completion. Nevertheless, successful portfolio completion was related to factors other than protected time in the echocardiography... read more
CRT-targeted Fluid Resuscitation vs. Lactate-targeted in Septic Shock
Capillary refill time (CRT)-targeted fluid resuscitation in septic shock was not superior to a lactate-targeted one on early fluid administration or fluid balances. However, it was associated with comparable effects on regional... read more
Trends in Time to Extubation for Pediatric Postoperative Cardiac Patients
In this large, multicenter database study, early extubation rates in postoperative cardiac patients did not significantly change between 2009 and 2018. Centers that performed early extubation more frequently did not have... read more
