Tag: study
Ventriculo-Arterial Coupling Analysis Predicts the Hemodynamic Response to Norepinephrine in Hypotensive Postoperative Patients
In patients with arterial hypotension norepinephrine increased end-systolic ventricular elastance and arterial elastance. The effects of norepinephrine on stroke volume depend on baseline ventriculo-arterial coupling. Although... read more
Processed Electroencephalography-guided General Anaesthesia to Reduce Postoperative Delirium
Our primary analysis demonstrated a highly sensitive result with a pooled analysis of trials in which the intervention group adhered to manufacturer's recommended guidelines showing reduced incidence of postoperative delirium... read more
90% of ECMO-eligible COVID-19 Patients Died Amid Rationing
Nearly 90% of adult COVID-19 patients who were eligible for—but didn't receive—extracorporeal membrane oxygenation (ECMO) during the height of the pandemic died in the hospital owing to a lack of resources, even though... read more
Patients’ Perspectives on Point-of-Care Diagnostics in Acute COPD Exacerbations
Patients' perspectives showed that point-of-care diagnostics and treatment of acute COPD in exacerbation was considered a qualitative offer by the patients and their relatives. At the same time, it was crucial that the emergency... read more
Clinical Profile and Recovery Pattern of Dysphagia in COVID-19 Patients
COVID-19 considerably impacted swallowing function in the current study. Although many patients recovered within an acceptable timeframe, some experienced persistent severe dysphagia and a protracted recovery with dependence... read more
Cancer Treatments Not Associated with Inferior COVID-19 Outcomes
The findings of this study of patients with active cancer suggest that recent systemic anticancer treatments (SACTs) is not associated with inferior outcomes from COVID-19 infection. This has relevance for the care of... read more
Arterial pH with Hemodynamic Response Association to Vasopressin in Patients with Septic Shock
Compared with higher arterial pH, patients with septic shock and low arterial pH had lower odds of vasopressin response and higher catecholamine doses after vasopressin initiation. Similar to other vasopressors, the clinical... read more
Ventilator Capacity Management Queuing Model During COVID-19 Pandemic
We applied a queuing model to inform ventilator capacity planning during the first wave of the COVID-19 epidemic in the province of British Columbia (BC), Canada. The core of our framework is a multi-class Erlang loss model... read more
Ethnic Differences in COVID-19 Mortality in the 2nd and 3rd Waves of the Pandemic in England
Public health strategies to increase vaccination uptake in ethnic minority groups could reduce disparities in COVID-19 mortality that cannot be accounted for by pre-existing risk factors. Age-adjusted HRs of death involving... read more
Virtual Craniofacial Clinic Outcomes for Assessing Plagiocephaly During the COVID-19 Pandemic
Virtual clinic encounters resulted in comparable diagnostic accuracy. The trend toward frequent follow-up assessments and changes in the final diagnosis in the virtual clinic cohort has indicated a level of diagnostic uncertainty... read more
Procalcitonin in the ED: The evidence
Is procalcitonin of any value in the emergency department? Considering that procalcitonin testing is not available in any of my hospitals, I have never been all that interested in this question. But Swami requested a procalcitonin... read more
Postintubation Sedation Administration in the Pediatric ED
Most pediatric patients do not receive PIS within an adequate time frame. Patients who receive long-acting paralytic agents are much less likely to be adequately sedated after rapid sequence intubation (RSI) compared with... read more
Hemodynamic Status During Endovascular Stroke Treatment
In our protocol-based setting, intraprocedural pre-recanalization BP reductions during endovascular therapy were not associated with functional outcome. However, higher intraprocedural pre-recanalization SBP and MAP were... read more
Estimated and Measured Post-tetanic Count Effect
Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block. Our findings indicate that using plasma concentrations of rocuronium bromide estimated with either of... read more
Percutaneous vs. Surgical Cannulation for Femoro-Femoral VA-ECMO in Cardiogenic Shock Patients
Compared with surgical cannulation, percutaneous cannulation was independently associated with lower in-hospital mortality and fewer complications. Among 12,592 patients meeting study inclusion, 9,249 (73%) underwent percutaneous... read more
Defining COVID-19 Associated Pulmonary Aspergillosis
The reported prevalence of CAPA in ICU patients with COVID-19 varies greatly by study and may be related to surveillance protocols and inconsistent definitions which may inflate the prevalence of this complication. Further... read more
Predicting Sepsis Severity at First Clinical Presentation
The severity and endotype signatures indicate that distinct immune signatures precede the onset of severe sepsis and lethality, providing a method to triage early sepsis patients. Gene expression signatures were obtained... read more
Resuscitation Using ECPR During In-Hospital Cardiac Arrest Mortality Prediction Score
The RESCUE-IHCA score can be used by clinicians in real time to predict in-hospital death among patients with in-hospital cardiac arrest (IHCA) who are treated with extracorporeal cardiopulmonary resuscitation (ECPR). A... read more
Intravenous Vitamin C Administration to Septic Shock Patients
Our pilot study indicated that intravenous vitamin C did not provide significant decreases in the mean dose or duration of vasopressor infusion. Further research that takes into account the potential impact of intervention... read more
ARDS Subphenotypes Validation and Utility Identified by Machine-learning Models
Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies... read more
Equipotent Ratios for the Most Common Vasopressors
Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more
