Tag: trauma
Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients
Quetiapine may decrease mortality and improve neurological outcomes in critically-ill traumatic brain injury (TBI) patients. It has a dose-dependent effect to decrease intracranial pressure (ICP) and increase cerebral perfusion... read more
Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients
In major trauma patients, overall stomach volume deriving from food, fluids and air must be expected to be around 400–500 mL. Gastric dilation caused by air is common but not typically associated with pre-hospital airway... read more
Intracerebral Hemorrhage (ICH)
For most patients, the best treatment seems to be high-quality supportive care. Aggressive interventions (e.g., causing dramatic drops in blood pressure and "prophylactic" hypertonic saline) may cause more harm than good. Cerebellar... read more
Haloperidol for Treatment of Headache in the ED
Headache is a common chief complaint that emergency physicians encounter almost every day and sometimes multiple times in each shift. In fact, headache is the fifth leading cause of patients presenting to the emergency department... read more
TOP KNIFE: The Art & Craft of Trauma Surgery
A practical guide to operative trauma surgery for residents and registrars, for general surgeons with an interest in trauma, and for isolated surgeons operating on wounded patients in military, rural or humanitarian settings.... read more
Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage
These data demonstrate that trauma-induced immunosuppression is characterized by an interleukin-10-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves outcome by limiting this... read more
Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation
Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be facilitated by... read more
Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis
There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more
Prevention and Treatment of ALI with Time-controlled Adaptive Ventilation
Neither the current lung protect and rest nor open lung approach (OLA) ventilation strategies have been effective at reducing VILI and ARDS-related mortality below that in the ARMA study. For a protective ventilation strategy... read more
50 Studies Every Intensivist Should Know
50 Studies Every Intensivist Should Know presents key studies that have shaped the practice of critical care medicine. Selected using a rigorous methodology, the studies cover topics including: sedation and analgesia, resuscitation,... read more
Big Data to Help Predict Individual Trauma Patient Outcome
Chinese researchers are using big data to help identify trauma patients who could experience potential adverse health events in the emergency department through the aid of a clinical decision support system. It was developed... read more
How COVID-19 is Affecting Trauma Systems in Italy
Italy is the first Western nation to experience the full impact of coronavirus disease. The pandemic is stretching the country's ability to care for older adults and patients with serious underlying medical conditions. But... read more
Focus on Clinical Trial Interpretation
In a recently published meta-epidemiological study of 604 randomised clinical trials (RCTs) published between 1977 and 2018 from 53 Cochrane systematic reviews in critical care, less than 7% of the RCTs had overall low risk... read more
Guidelines for Burn Care Under Austere Conditions
The principles of care after disasters and mass casualty incidents are centered on doing the greatest good for the greatest number. From an airway and ventilation perspective, we have presented the issues that are likely... read more
Validation of Neuromuscular Blocking Agent Use in ARDS
The use of Neuromuscular Blocking Agents (NMBA) could significantly decrease mortality in moderate-to-severe acute respiratory distress syndrome (ARDS) patients and decrease the incidence of barotrauma during mechanical ventilation.... read more
Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century
Distracted by the high mortality rate of critical illness, we tend to overlook the essential fact that most patients survive the intensive care unit (ICU). Every year, millions of patients are discharged from the ICU... read more
eFAST Performance with a Novel vs. Conventional Transducers
Point-of-injury extended focused assessment with sonography in trauma (eFAST) may identify life-threatening torso hemorrhage and expedite casualty evacuation. The purpose of this study was to compare combat medic eFAST performance... read more
Tranexamic Acid in TBI – CRASH-3 Trial Treatment
The CRASH-3 trial is a multi-centre, randomised, placebo-controlled trial of the effects of tranexamic acid on death and disability in patients with traumatic brain injury (TBI). Patients with reactive pupils and/or mild... read more
Epinephrine During Resuscitation of Traumatic Cardiac Arrest and Increased Mortality
Epinephrine administered during in-hospital resuscitation was associated with lower 7-day survival rate in patients with out-of-hospital cardiac arrest (OHCA) following trauma. While we examined the outcomes of selected... read more
Tranexamic Acid Has Nominal Benefit for TBI
Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting... read more
Early Psychological Screening of ICU Survivors
Symptoms of post-traumatic stress, anxiety and depression assessed 1 week after ICU stay correlate with 3-month psychological outcome. The HADS and PTSS-10 may be useful aids to identify ICU survivors at high risk for... read more
ICU Bouncebacks Associated with Worse Outcomes
ICU Bouncebacks (ICUBBs) are associated with worse outcomes and are disproportionately burdened by respiratory complications. These findings emphasize the importance of the TQIP Collaborative in identifying statewide... read more
