Haloperidol for Treatment of Headache in the ED

Haloperidol for Treatment of Headache in the ED

Headache is a common chief complaint that emergency physicians encounter almost every day and sometimes multiple times in each shift. In fact, headache is the fifth leading cause of patients presenting to the emergency department... read more

TOP KNIFE: The Art & Craft of Trauma Surgery

TOP KNIFE: The Art & Craft of Trauma Surgery

A practical guide to operative trauma surgery for residents and registrars, for general surgeons with an interest in trauma, and for isolated surgeons operating on wounded patients in military, rural or humanitarian settings.... read more

Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage

Hydrocortisone Prevents Immunosuppression by interleukin-10+ Natural Killer Cells After Trauma-Hemorrhage

These data demonstrate that trauma-induced immunosuppression is characterized by an interleukin-10-dependent elimination of dendritic cell by natural killer cells and that hydrocortisone improves outcome by limiting this... read more

Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation

Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation

Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be facilitated by... read more

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more

Prevention and Treatment of ALI with Time-controlled Adaptive Ventilation

Prevention and Treatment of ALI with Time-controlled Adaptive Ventilation

Neither the current lung protect and rest nor open lung approach (OLA) ventilation strategies have been effective at reducing VILI and ARDS-related mortality below that in the ARMA study. For a protective ventilation strategy... read more

50 Studies Every Intensivist Should Know

50 Studies Every Intensivist Should Know

50 Studies Every Intensivist Should Know presents key studies that have shaped the practice of critical care medicine. Selected using a rigorous methodology, the studies cover topics including: sedation and analgesia, resuscitation,... read more

Big Data to Help Predict Individual Trauma Patient Outcome

Big Data to Help Predict Individual Trauma Patient Outcome

Chinese researchers are using big data to help identify trauma patients who could experience potential adverse health events in the emergency department through the aid of a clinical decision support system. It was developed... read more

How COVID-19 is Affecting Trauma Systems in Italy

How COVID-19 is Affecting Trauma Systems in Italy

Italy is the first Western nation to experience the full impact of coronavirus disease. The pandemic is stretching the country's ability to care for older adults and patients with serious underlying medical conditions. But... read more

Focus on Clinical Trial Interpretation

Focus on Clinical Trial Interpretation

In a recently published meta-epidemiological study of 604 randomised clinical trials (RCTs) published between 1977 and 2018 from 53 Cochrane systematic reviews in critical care, less than 7% of the RCTs had overall low risk... read more

Guidelines for Burn Care Under Austere Conditions

Guidelines for Burn Care Under Austere Conditions

The principles of care after disasters and mass casualty incidents are centered on doing the greatest good for the greatest number. From an airway and ventilation perspective, we have presented the issues that are likely... read more

Validation of Neuromuscular Blocking Agent Use in ARDS

Validation of Neuromuscular Blocking Agent Use in ARDS

The use of Neuromuscular Blocking Agents (NMBA) could significantly decrease mortality in moderate-to-severe acute respiratory distress syndrome (ARDS) patients and decrease the incidence of barotrauma during mechanical ventilation.... read more

Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century

Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century

Distracted by the high mortality rate of critical illness, we tend to overlook the essential fact that most patients survive the intensive care unit (ICU). Every year, millions of patients are discharged from the ICU... read more

eFAST Performance with a Novel vs. Conventional Transducers

eFAST Performance with a Novel vs. Conventional Transducers

Point-of-injury extended focused assessment with sonography in trauma (eFAST) may identify life-threatening torso hemorrhage and expedite casualty evacuation. The purpose of this study was to compare combat medic eFAST performance... read more