Tag: treatment
Harmonizing Heterogeneous Endpoints in COVID-19 Trials Without Loss of Information
All ongoing clinical trials should include a stacked probability plot in their statistical analysis plan as descriptive analysis. While primary analysis should be on an early endpoint with appropriate capability to be... read more
Lactoferrin for the Treatment of COVID‑19
The coronavirus disease 2019 (COVID‑19) outbreak was caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The clinical outcomes of elderly individuals and those with underlying... read more
Modifiable Factors Associated With Chronic Pain After Surgery for Distal Radius Fractures
In this study, preoperative pain, time to surgery, and procedure type were modifiable factors associated with chronic pain 1 year after DRF treated with surgery. Adequate pain control in patients with acute DRFs even... read more
Childhood sepsis deadlier for Black patients
In this large, representative analysis of paediatric severe sepsis in the USA, we found evidence of outcome disparities by race or ethnicity and insurance status. Our findings suggest that there might be differential... read more
Evaluation and Treatment of Renal and Perinephric Abscesses
A 30-year-old woman with past medical history of type 2 diabetes presents to the emergency department with 3 days of vague abdominal/back pain, with associated subjective fever, chills, nausea and vomiting. She states she... read more
PEM Playbook – Pediatric Pain
Pain is multifactorial: it is comprised of physical, psychological, emotional, cultural, and contextual features. In children often the predominant feature may not be initially apparent. Although clinicians may focus on... read more
ED Evaluation and Management of Non-Obstetric Abdominal Pain in the Pregnant Patient
A 27-year-old G4P2 female at 25-weeks gestation presents to the emergency department with right upper quadrant abdominal pain. The pain began yesterday and was initially a generalized discomfort that localized to the right... read more
Apoptotic cells for therapeutic use in cytokine storm associated with sepsis
Sepsis has no proven specific pharmacologic treatment. Reported mortality in sepsis ranges from 30%-45%. This study was designed to determine the safety preliminary efficacy of allogenic apoptotic cells administered for immunomodulation... read more
Caring for the Sickest COVID-19 Patients: An ICU Story
In an article for the latest issue of Stanford Medicine magazine, I provide a glimpse into the journey Free and his front-line Stanford Health Care colleagues took -- from Day 1 through the following weeks and months -- to... read more
COVID-19 and ARDS: The Baby Lung Size Matters
COVID-19 in its initial manifestations has strikingly peculiar characteristics (e.g., hypoxemia with vasocentric injury and high gas lung volume), is so evident that atypical ARDS should not be a matter of further discussion.... read more
Sick Meningitis, POCUS for Pneumoperitoneum, and Treatment of CHS
Today on the emDocs cast with Brit Long, MD (@long_brit) and Manpreet Singh, MD (@MprizzleER) we cover three posts: the sick meningitis patient, ultrasound for pneumoperitoneum, and treatment of cannabiniod hyperemesis syndrome. Part... read more
Predictors of QT Interval Prolongation in Critically-ill Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine
Hydroxychloroquine (HCQ) has been described as a potential treatment for SARS-CoV-2 infection. However, there are safety concerns regarding its QT interval and pro-arrhythmic effects. This trial aimed to determine the... read more
Miles Sibley: We need to change the hierarchy of evidence-based medicine
In July 2020, the Independent Medicines and Medical Devices Safety Review published a report entitled “First Do No Harm”. Also known as the Cumberlege Review, the report set out extensive evidence of avoidable harm in... read more
Resilience in a Prehospital Setting – A New Focus for Future Research?
Empirical research is of crucial importance to understand, build and support resilient systems and processes, including exploring and developing interventions to improve capacity for adaptive change in a prehospital setting. Handling... read more
Effect of Tocilizumab vs. Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia
The administration of tocilizumab in patients with COVID-19 pneumonia and a Pao2/Fio2 ratio between 200 and 300 mm Hg did not reduce the risk of clinical worsening. Further blinded, placebo-controlled randomized clinical... read more
