Music Therapy Intervention to Treat Sedation-Related Delirium in Critical Care

Music Therapy Intervention to Treat Sedation-Related Delirium in Critical Care

Sedation is an essential component of treatment for some patients admitted to the intensive care unit, but it carries a risk of sedation-related delirium. Sedation-related delirium is associated with higher mortality and... read more

Higher Dose Antibiotic Shown Safe in TB Patients Likely More Effective in Treating Deadliest Form of TB

Higher Dose Antibiotic Shown Safe in TB Patients Likely More Effective in Treating Deadliest Form of TB

A Johns Hopkins Children’s Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that... read more

Sepsis is scurvy? Vitamin C, Thiamine, and Steroids

Sepsis is scurvy? Vitamin C, Thiamine, and Steroids

I have avoided commenting on vitamin C for sepsis, because commentary seemed rather unnecessary. The hype was obviously ridiculous. The chances of it helping were clearly low. The evidence of benefit was negligible. Others... read more

HFNO Alone or Alternating with NIV in ARF Patients

HFNO Alone or Alternating with NIV in ARF Patients

In critically ill immunocompromised patients with acute respiratory failure (ARF), the mortality rate did not differ between HFNO alone and non-invasive ventilation (NIV) alternating with high-flow nasal oxygen (HFNO). However,... read more

Obstructive Airway Diseases: Role of Lipid Mediators

Obstructive Airway Diseases: Role of Lipid Mediators

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is... read more

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who received less than 10 days of corticosteroids during hospitalization... read more

Sotrovimab Effect Among High-risk COVID-19 Patients

Sotrovimab Effect Among High-risk COVID-19 Patients

Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more

Critically Ill Pregnant Women with COVID-19: Management and Outcome

Critically Ill Pregnant Women with COVID-19: Management and Outcome

Coronavirus disease 2019 (COVID-19)-infected pregnant women are at higher risk of intensive care unit (ICU) admission and mechanical ventilation. Because reports describing the clinical course and management of critically... read more

Percussion Pacing – An Almost Forgotten Procedure for Hemodynamically Unstable Bradycardias?

Percussion Pacing – An Almost Forgotten Procedure for Hemodynamically Unstable Bradycardias?

More than 80 years after its first description by Eduard Schott, percussion (fist) pacing remains a little known procedure even though it represents an instantly available and easy to perform treatment for temporary emergency... read more

Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema

This study compared the effect of placebo versus the bradykinin B2 receptor antagonist icatibant on symptoms of ACE inhibitor–associated angioedema in a mixed race population of patients. The study does not support the... read more

Buprenorphine-Precipitated Opioid Withdrawal in the ED

Buprenorphine-Precipitated Opioid Withdrawal in the ED

Buprenorphine-precipitated opioid withdrawal is seen in patients physically dependent on opioids who have recently taken full-agonist opioids and are then administered buprenorphine. Patients with severe withdrawal commonly... read more

Clinical, Biological and Molecular Aspects of COVID-19

Clinical, Biological and Molecular Aspects of COVID-19

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the... read more

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill

As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia

Lung Ultrasonography Beyond the Diagnosis of Pediatrics Pneumonia

Pneumonia is a prevalent disease with considerable morbidity and mortality among the pediatric population. Early diagnosis and swift commencement of the correct treatment are vital for a favorable clinical outcome. Along... read more

Pediatric Pneumonia Research Priorities in the Context of COVID-19

Pediatric Pneumonia Research Priorities in the Context of COVID-19

Operational research on health system capacities, and evaluating optimized delivery of existing treatments, diagnostics and case management approaches are needed. This list should act as a catalyst for collaborative research,... read more

Patients’ Perspectives on Point-of-Care Diagnostics in Acute COPD Exacerbations

Patients’ Perspectives on Point-of-Care Diagnostics in Acute COPD Exacerbations

Patients' perspectives showed that point-of-care diagnostics and treatment of acute COPD in exacerbation was considered a qualitative offer by the patients and their relatives. At the same time, it was crucial that the emergency... read more

Information Transfer as a Strategy to Improve Safety in ICU

Information Transfer as a Strategy to Improve Safety in ICU

In an Intensive Care Unit (ICU), we attend people with a wide range of pathologies. All the information obtained from monitoring our critical patients, diagnostic and therapeutic techniques, responses to treatments, action... read more