Use and Outcomes of Nasotracheal Intubation Among Patients Requiring Mechanical Ventilation Across U.S. PICUs
Nasotracheal intubation is used in a minority of U.S. PICUs and mainly among young cardiac patients. Nasotracheal intubation is associated with a lower rate of unplanned extubations in this patient population. Future... read more
LV Overloading Identified by Critical Care Echocardiography is Key in Weaning‑induced Pulmonary Edema
Spontaneous breathing trial (SBT) failure due to WIPO appears related to overloaded LV, including the worsening or development of mitral regurgitation, associated with excessive accumulated fluid balance. SBT-induced central... read more
Factors Behind Decline of VV ECMO to Support Neonatal Respiratory Failure
The majority of U.K. centers are unable to provide venovenous extracorporeal membrane oxygenation (VV ECMO) for neonates due to concerns with availability and suitability of dual lumen cannulae. An alternative to be considered... read more
Pragmatic Approach to Inpatient Diabetes Management During COVID-19
The pandemic of COVID-19 has presented new challenges to hospital personnel providing care for infected patients with diabetes who represent more than 20% of critically ill patients in ICUs. Appropriate glycemic management... read more
From Russia with Love – “Sputnik V” COVID-19 Vaccine Generated an Immune Response
Between June 18 and Aug 3, 2020, Ministry of Health of the Russian Federation enrolled 76 participants to the two studies (38 in each study). In each study, 9 volunteers received rAd26-S in Phase 1, nine received rAd5-S in... read more
Sepsis and COVID-19: Perspectives From a Sepsis Coordinator
Coronavirus disease 2019 (COVID-19) has brought difficulties and disruptions to all corners of the world. As a sepsis coordinator, I can attest that the scientific and healthcare community in the United States has been particularly... read more
COVID-19: A Critical Analysis of Chloroquine and Hydroxychloroquine Clinical Pharmacology
Chloroquine and hydroxychloroquine have been used for over 60 years in the treatment of malaria, amoebic liver abscess, and several rheumatological conditions, but their clinical pharmacology is not well understood. COVID-19... read more
Hydroxychloroquine With or Without Azithromycin
Among patients hospitalized with mild-to-moderate COVID-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. A total of 667 patients... read more
Effects of Telemedicine ICU Intervention on Care Standardization and Patient Outcomes
In this pre-post observational study, telemedicine ICU intervention was associated with improvements in care standardization and decreases in ICU and hospital mortality and length of stay. The mortality benefits were mediated... read more
Bedside ECHO To Diagnose Native Valve Infective Endocarditis
Infective endocarditis (IE) is an important pathology to detect in the Emergency Department (ED), but the diagnosis is too often delayed or missed. IE ticks many boxes as a diagnosis we can "own" in Emergency Medicine (EM): 1.... read more
Training Multidisciplinary Healthcare Workers to Reinforce ICUs in Times of Need
ESICM is to carry out a C19 SPACE programme funded by the European Commission for the training of multidisciplinary healthcare professionals not regularly working in ICUs, to give extra support to ICUs during the COVID-19... read more
Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19
Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority... read more
CDC Tells States How to Prepare for Covid-19 Vaccine by Early November
The Centers for Disease Control and Prevention has notified public health officials in all 50 states and five large cities to prepare to distribute a coronavirus vaccine to health care workers and other high-risk groups as... read more
Survey Finds More Than Half of Pediatric Cardiology Nurses Are Burned Out
More than half of nurses caring for children with cardiovascular conditions are emotionally exhausted and good working environments were linked with less burnout, according to a survey presented during ESC Congress 2020. Of... read more
Steroids Confirmed to Help Severely Ill COVID-19 Patients
In patients hospitalized with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those... read more
Obesity and the Risk of Intubation or Death in Patients with COVID-19
Among consecutive patients hospitalized with coronavirus disease 2019, obesity was an independent risk factor for intubation or death. A total of 305 patients were included in this study. We stratified patients by body... read more
Bacterial Profile of Ventilator Associated Pneumonia: Concept, Review, Methods, Observations, Inference
ICU is a hotbed of infections and measures are taken to prevent these infections. Ventilator associated pneumonia is one of the Intensive Care Unit related infections. This book tells us what ventilator associated pneumonia... read more
Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
Among patients receiving recommended therapy for heart failure, those in the empagliflozin group had a lower risk of cardiovascular death or hospitalization for heart failure than those in the placebo group, regardless of... read more
Principles Guiding Non Pandemic Critical Care Research During a Pandemic
Deliberation about continuing non pandemic research should use objective, transparent criteria considering several aspects of the research process such as bedside and research staff safety, infection control, the informed... read more
Limiting Radiation in Trauma Imaging & Trauma Resuscitation
Appropriate clinical decision-making in the initial evaluation and management of trauma patients in the emergency department is critical to optimize patient outcomes. This supplement provides evidence-based recommendations... read more
Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes
Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies... read more
Shorter Resident Shifts May Not Improve Patient Safety
Residents who worked schedules that eliminated extended shifts made a greater number of serious errors than those who worked schedules with shifts of 24 or more hours, a trial in the New England Journal of Medicine reported. The... read more
