Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients
Quetiapine may decrease mortality and improve neurological outcomes in critically-ill traumatic brain injury (TBI) patients. It has a dose-dependent effect to decrease intracranial pressure (ICP) and increase cerebral perfusion... read more
ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster
ICU Doctor Chandar Abboy and his partner came up with a way to give a voice to the voiceless. The app called “Yo Doc” allows patients on ventilators to better communicate their needs and feelings. Dr. Abboy says this... read more
Anaphylatoxin C5a Impairs Phagocytosis by Neutrophils
This study provides new insight into the mechanisms underlying immunocompromise in critical illness and suggests novel avenues for therapy and prevention of nosocomial infection. Critically ill patients are at heightened... read more
Comparing Procedural Amnesia and Respiratory Depression vs. MS and DS with Propofol
Targeting moderate sedation (MS) or deep sedation (DS) did not reliably result in the intended sedation level. Targeting MS, however, resulted in a lower rate of total AREs and fewer patients had multiple AREs with no difference... read more
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more
The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19
COVID-19 related cardiopulmonary failure such as ARDS and cardiogenic shock or massive pulmonary embolism can be successfully supported with ECMO. Judicious patient selection is important to enable maximal benefit and optimized... read more
Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status
Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more
Physiologic Assessment: Variation in Fluid and Vasopressor Use in Shock
The decision whether to give more fluid during the management of shock can be somewhat provider-dependent. This multicenter prospective cohort study evaluated 1639 patients with hypotension requiring vasopressors. The... read more
Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19
Patients with coronavirus disease 2019 (COVID-19) can develop acute respiratory distress syndrome (ARDS), which has been linked to poor prognosis and is a major contributor to patient death. A better understanding of the... read more
Holding and Mobility of Pediatric Patients With Transthoracic Intracardiac Catheters
Pediatric patients with transthoracic intracardiac catheters can be safely held and mobilized out of bed. A total of 1,358 patients had activity and positioning documented while transthoracic intracardiac catheters were... read more
Massive PE with Intra-hospital Cardiac Arrest and Full Recovery of RV Function after vaECMO
The concept of vaECMO treatment alone might be a valuable alternative in selected patients with massive PE and cardiogenic shock, in whom thrombolytic therapy might not unload the RV fast enough. We present a case of a... read more
Lange Critical Care
LANGE Critical Care delivers concise, evidenced-based, and highly clinical coverage of the surgical and medical aspects of critical care. The book provides basic fundamentals, applications and insights that will be of lasting... read more
Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients
In major trauma patients, overall stomach volume deriving from food, fluids and air must be expected to be around 400–500 mL. Gastric dilation caused by air is common but not typically associated with pre-hospital airway... read more
Surgery of the Inferior Vena Cava
This book addresses an urgent need, offering an updated, detailed and multidisciplinary review of surgery of the inferior vena cava (IVC). Over the past two decades, tremendous advances have been made in this field and related... read more
Perioperative Management of Glucose-lowering Drugs in Type 2 Diabetes Patients
Patients with type 2 diabetes are commonly referred for elective or emergency surgery. In case of scheduled surgical procedures, previous guidelines recommended to withhold oral glucose-lowering drugs. Based on recent... read more
Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic
The evaluation and treatment of acute large vessel occlusion stroke present many challenges during the COVID-19 era. It may be difficult to screen stroke patients for COVID-19 symptoms because of encephalopathy or aphasia.... read more
Substituting Acetaminophen for Fentanyl Feasible in PCI for STEMI
In patients with STEMI given crushed ticagrelor before PCI, using IV acetaminophen instead of IV fentanyl as a painkiller did not increase pain levels or platelet reactivity and prevented delay of ticagrelor's effects, researchers... read more
COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis
Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more
Ground-breaking Research – Venous Thrombosis is Back in Business
The primary efficacy outcome was the development of a major venous thromboembolic event such as symptomatic distal or proximal deep-vein thrombosis, asymptomatic deep vein thrombosis, pulmonary embolism or venous thromboembolism–related... read more
Inhaled Pulmonary Vasodilators
Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more
Working in ICU is like Flying a Plane: The Secret World of Intensive Care
Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more
Aerosol and Surface Distribution of SARs-CoV-2 in Hospital Wards
In a hospital treating COVID-19 patients, SARS-CoV-2 RNA was found widely distributed in surface and air samples. Contamination was greater in intensive care units (54/124 samples) than general wards (9/114 samples). A... read more
