Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF
Persistent respiratory morbidity develops in up to potentially 44% of previously healthy children less than or equal to 24 months old at follow-up after acute respiratory failure (ARF) requiring mechanical ventilation. This... read more
Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19
Recent studies have provided insights into the pathogenesis of COVID-19. Yet, longitudinal immunological correlates of disease outcome remain unclear. Here, we serially analysed immune responses in 113 COVID-19 patients with... read more
High Breath-by-Breath Variability Is Associated With Extubation Failure in Children
High respiratory variability during spontaneous breathing trials is independently associated with extubation failure in children, with very high rates of extubation failure when these children develop postextubation upper... read more
Presence of Genetic Variants Among Young Men With Severe COVID-19
In this case series of 4 young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses. These preliminary... read more
What Nursing Homes Can Teach EMS About COVID-19
Most EMS providers are familiar with long-term skilled nursing facilities, yet most of us don't think much about them. We certainly don't think they can teach us much. Nursing homes have been hit hard by COVID-19 and... read more
Who Gets to Live? How Doctors Make Impossible Decisions as COVID-19 Surges
Triage aims to provide the greatest amount of good for the greatest number, but medical staff are grappling with how to stay true to this principle as coronavirus surges. 18 states are currently in what's considered the... read more
Intracerebral Hemorrhage (ICH)
For most patients, the best treatment seems to be high-quality supportive care. Aggressive interventions (e.g., causing dramatic drops in blood pressure and "prophylactic" hypertonic saline) may cause more harm than good. Cerebellar... read more
A Concise Overview of Non-invasive IAP Measurement Techniques
This review presents an overview of previously reported non-invasive intra-abdominal pressure (IAP) measurement techniques. Each section covers the basic physical principles and methodology of the various measurement techniques,... read more
30% of COVID-19 Patients Had No Symptoms of Fever, Cough, or Shortness of Breath
The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic... read more
Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery
A FF strategy was not associated with changes to early enteral nutrition delivery. Inflammation, insulin resistance, and morbidity were similar, but FF may modify the relationship between inflammation and adverse event. Multicenter... read more
Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19
In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more
Review of Viral Testing and Antibody/Serology Testing for COVID-19 for the Intensivist
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) pandemic has led to the rapid development of many diagnostic tests. The initial focus of these tests was on molecular... read more
Dexmedetomidine for Prolonged Sedation in the PICU
High-quality data on dexmedetomidine use for prolonged sedation and a consensus on correct dosing and weaning protocols in children are currently missing. Infusion of dexmedetomidine can be considered relatively safe in pediatrics... read more
COVID-19: A Hypothesis Regarding the Ventilation-Perfusion Mismatch
We believe that a severe V/Q mismatch underlies the pathophysiology of moderate to severe COVID-19 cases, in which downregulation of ACE2 secondary to viral endocytosis plays a key role. There is low V/Q ratio in areas of... read more
Preventing Major Airway Complications
Every anaesthetist fears the moment they might become faced with a "can't intubate, can't oxygenate" (CICO) scenario, but thankfully such events are exceedingly rare. They nevertheless receive much attention in the academic... read more
Bedside PUG Tube Placement by Critical Care Physicians
Critically ill patients often require gastrostomy tubes. Percutaneous endoscopic gastrostomy has become the most common method of placement but is not widely performed by critical care physicians, in part due to their lack... read more
The Application of 6S and PDCA Management Strategies in the Nursing of COVID-19 Patients
Overall, the management of the nursing team followed the PDCA (Plan-Do-Check-Act) cycle management principle as described in a previous study, thus enabling real-time planning, execution, inspection and improvement. During... read more
Critical Care and Hospitalist Medicine Made Ridiculously Simple
A fundamental and thorough guide to the treatment of hospitalized patients in critical care situations, "Critical Care and Hospitalist Medicine Made Ridiculously Simple" provides both introductory information as well as a... read more
POCUS is Having Its Moment
Ultrasound performed at the point of care (POCUS) is having its moment. The COVID-19 pandemic has seemingly caused the acceleration of POCUS acceptance by hospital leaders, and POCUS examinations are increasingly performed... read more
Factors Associated With Death in Critically Ill Patients With COVID-19 in the US
This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies... read more
Infectious Meningitis and Encephalitis in ICU
Infectious meningitis and encephalitis are a major concern in ICU since they are associated with high mortality and permanent neurological injury. About 3% of central nervous system infections will be admitted in the ICU. Three... read more
Moderna mRNA Vaccine Candidate’s Phase I Trial
Eight weeks to the day after press-releasing some top line results, the full paper is out on the Moderna mRNA vaccine candidate’s Phase I trial. I'm very glad to see it – it's going to be very important for the full data... read more
