Lifting the Impenetrable Veil: From Yellow Fever to Ebola Hemorrhagic Fever & SARS
This book tells their communal story, the story of medical history, entomology, vector-borne diseases, virology, epidemiology and related fascinating but little recognized disciplines Interweaving his own personal stories... read more
Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage
Reduced glucose variability is highly correlated with in-patient survival and long-term mortality in subarachnoid hemorrhage (aSAH) patients. This finding was observed in the non-diabetic and well-controlled diabetic patients,... read more
Ventilatory Support and Mechanical Properties of the Fibrotic Lung Acting as a “Squishy Ball”
The management of the patient with lung fibrosis in the ICU is a challenge for the intensivist. The lack of studies defining the mechanical ventilation strategy, and the different underlying etiologies, make it difficult... read more
Expiratory Muscle Dysfunction in Critically Ill Patients
The expiratory muscles are the "neglected component" of the respiratory muscle pump. Rather as the heart does not comprise only a left ventricle, but also a right one, the respiratory muscle pump is much more than just the... read more
Influence of Head-of-bed Elevation on the Measurement of IVC Diameter and Collapsibility
In a population of critically ill patients undergoing goal-directed ultrasound examinations, elevating head-of-bed (HOB) to 30° did not significantly alter inferior vena cava (IVC) measurements or CI. At 45°, however,... read more
Molecular Biology of the SARS-Coronavirus
SARS was the first new plague of the twenty-first century. Within months, it spread worldwide from its "birthplace" in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across five continents.... read more
2019 Novel Coronavirus Stakeholder Listening Session Transcript
In response to the 2019 Novel Coronavirus (2019-nCoV) outbreak, the federal government is taking steps to protect the country. Within the U.S. Department of Health and Human Services, the Office of the Assistant Secretary... read more
How Do We Test for Coronavirus?
Centers for Disease Control (CDC), published methodology for 2019-Novel Coronavirus (2019-nCoV) testing and is currently in the process of applying for an emergency waiver to allow medical-testing facilities to perform these... read more
Global, Regional, and National Sepsis Incidence and Mortality: 1990-2017
Globally, there were an estimated 60.2 million cases of sepsis in 1990 and 48.9 million cases of sepsis in 2017. This change represents a decrease of 18.8%. Of all incident cases of sepsis in 2017, 33.1 million occurred... read more
WHO Guidelines Regarding Fluid Administration for Coronarvirus Are Dangerously Misguided
Portions of the current WHO guidelines regarding fluid management are dangerously misguided. The first two recommendations suggest limiting fluid administration in patients with ARDS and patients who aren't shocked, to... read more
Soluble Urokinase Receptor and AKI
The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts. This cohort study reports that suPAR was associated with subsequent AKI in several... read more
A Team Response to a Potential Killer: Sepsis
Our bodies are very good at fighting infection. The immune system reacts and attacks bacteria and viruses that make us sick. But sometimes the immune reaction is so strong that it damages the body. This is called a septic... read more
Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO
Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more
Tranexamic Acid Has Nominal Benefit for TBI
Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting... read more
Sepsis: The Hour-1 Bundle, the Future of Research, and More
Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis. Drs. Parker and Levy go beyond the bundle to talk about... read more
Correction and Control of Hyperammonemia in Acute Liver Failure
Continuous renal replacement therapy (CRRT) is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous... read more
A Prospective Observational Study of High-Dose Intrathecal Diamorphine in Laparoscopic Bariatric Surgery
We have demonstrated that neuraxial blockade is a simple, practical, and feasible technique to adopt. Our case series demonstrated a high level of patient acceptability. 50 patients were included. 11 patients (22%) had... read more
AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU
Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... read more
The ABCDE Bundle Associated with Significant Reductions in Duration of Mechanical Ventilation
The focus on long-term consequences of critical illness has intensified with increasing ICU utilization and survivorship. Post Intensive Care Syndrome (PICS) is increasingly recognized and has profound and long-lasting negative... read more
Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort
In this cohort, the major risk factors for septicemia death were similar to those for other causes of death, there was approximately a 2-fold Black-White disparity in septicemia deaths, and the strongest mediators of this... read more
Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Infection
This interim guidance is for clinicians caring for patients with confirmed 2019 novel coronavirus (2019-nCoV) infection. CDC will update this interim guidance as more information becomes available. There are a limited... read more
Beta-Blocker Therapy in Severe TBI
Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more
