How Do We Test for Coronavirus?

Centers for Disease Control (CDC), published methodology for 2019-Novel Coronavirus (2019-nCoV) testing and is currently in the process of applying for an emergency waiver to allow medical-testing facilities to perform these... read more

Global, Regional, and National Sepsis Incidence and Mortality: 1990-2017

Globally, there were an estimated 60.2 million cases of sepsis in 1990 and 48.9 million cases of sepsis in 2017. This change represents a decrease of 18.8%. Of all incident cases of sepsis in 2017, 33.1 million occurred... read more

WHO Guidelines Regarding Fluid Administration for Coronarvirus Are Dangerously Misguided

Portions of the current WHO guidelines regarding fluid management are dangerously misguided. The first two recommendations suggest limiting fluid administration in patients with ARDS and patients who aren't shocked, to... read more

Soluble Urokinase Receptor and AKI

The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts. This cohort study reports that suPAR was associated with subsequent AKI in several... read more

A Team Response to a Potential Killer: Sepsis

Our bodies are very good at fighting infection. The immune system reacts and attacks bacteria and viruses that make us sick. But sometimes the immune reaction is so strong that it damages the body. This is called a septic... read more

Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO

Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more

Tranexamic Acid Has Nominal Benefit for TBI

Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting... read more

Sepsis: The Hour-1 Bundle, the Future of Research, and More

Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis. Drs. Parker and Levy go beyond the bundle to talk about... read more

Correction and Control of Hyperammonemia in Acute Liver Failure

Continuous renal replacement therapy (CRRT) is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous... read more

A Prospective Observational Study of High-Dose Intrathecal Diamorphine in Laparoscopic Bariatric Surgery

We have demonstrated that neuraxial blockade is a simple, practical, and feasible technique to adopt. Our case series demonstrated a high level of patient acceptability. 50 patients were included. 11 patients (22%) had... read more

AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU

Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... read more

The ABCDE Bundle Associated with Significant Reductions in Duration of Mechanical Ventilation

The focus on long-term consequences of critical illness has intensified with increasing ICU utilization and survivorship. Post Intensive Care Syndrome (PICS) is increasingly recognized and has profound and long-lasting negative... read more

Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort

In this cohort, the major risk factors for septicemia death were similar to those for other causes of death, there was approximately a 2-fold Black-White disparity in septicemia deaths, and the strongest mediators of this... read more

Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Infection

This interim guidance is for clinicians caring for patients with confirmed 2019 novel coronavirus (2019-nCoV) infection. CDC will update this interim guidance as more information becomes available. There are a limited... read more

Beta-Blocker Therapy in Severe TBI

Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more

Conservative vs. Interventional Treatment for Spontaneous Pneumothorax

Although the primary outcome was not statistically robust to conservative assumptions about missing data, the trial provides modest evidence that conservative management of primary spontaneous pneumothorax was noninferior... read more

Human-to-Human Transmission of a Novel Coronavirus in Vietnam

This article describe transmission of Coronavirus from a father, who had flown with his wife from Wuhan to Hanoi, to his son. The findings suggest that the incubation period in the son may have been 3 days or less. On... read more

WHO Declares the New Coronavirus Outbreak a Public Health Emergency of International Concern

The International Health Regulations Emergency Committee believes that it is still possible to interrupt virus spread, provided that countries put in place strong measures to detect disease early, isolate and treat cases,... read more

Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats

Local production of aldosterone by its processing enzyme aldosterone synthase within peripheral sensory neurons contributes to ongoing mechanical hypersensitivity during local inflammation via intrinsic activation of neuronal... read more

Neuroprognostication Practices in Postcardiac Arrest Patients

Neuroprognostic approaches to hypoxic-ischemic encephalopathy vary among physicians and are often not consistent with current guidelines. The overall inconsistency in approaches and deviation from evidence-based recommendations... read more

Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data

Systemic inflammatory response syndrome and Sequential Organ Failure Assessment initially identified distinct populations. Using systemic inflammatory response syndrome resulted in earlier electronic health record sepsis... read more

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality) compared with standard-issue red blood... read more