Effects of Sepsis on Mortality in Critically Ill Patients 2 Years After ICU Discharge
Compared with patients without sepsis, those with sepsis have higher mortality in the intensive care unit and have more pain, hospital readmissions, and functional decline within 2 years after discharge. During the study,... read more
Delayed Interhospital Transfer of Critically Ill Patients with Surgical Sepsis
Patients with surgical sepsis who spent more than 24 hours at an outside facility prior to transfer had greater initial illness severity, longer intervals between admission and source control, and more nosocomial infections... read more
Stress Management Intervention to Prevent PICS-Family in Patients’ Spouses
Sensation Awareness Focused Training (SĀF-T) intervention during the ICU stay is feasible, acceptable, and may improve family caregivers' post-ICU outcomes. Larger clinical trial to assess the effectiveness of SĀF-T in... read more
Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI
In adults with severe traumatic brain injury (TBI), prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital. A total of... read more
Association Between Hospital Staffing Models and Failure to Rescue
Low failure to rescue (FTR) hospitals had significantly more staffing resources than high FTR hospitals. Although hiring additional staff may be beneficial, there remain significant financial limitations for many hospitals... read more
Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU
Pediatric acute respiratory distress syndrome (ARDS) contributes to a significant burden in the PICU of a developing country and is associated with significantly higher mortality. Infection remains the most common etiology.... read more
The Fragility and Reliability of Conclusions of Anesthesia and Critical Care Randomized Trials With Statistically Significant Findings
Statistically significant results in anesthesia and critical care randomized controlled trials are often fragile, and study conclusions are frequently affected by spin. Routine calculation of the Fragility Index in medical... read more
Correlation Among Endothelial Injury, Organ Dysfunction, and Several Biomarkers in Sepsis Patients
Protein C was superior for the prediction of organ dysfunction after 7 days of ICU treatment when compared with other biomarkers of endothelial function, inflammation, and coagulation. C-reactive protein (CRP) and white blood... read more
A 10-Year Longitudinal Analysis of Protocol-Based Sepsis Management
This 10-year single-center retrospective cohort showed that the use of PB management of severe sepsis and septic shock was associated with a decreased hospital mortality for patients. This mortality benefit was preserved... read more
Epidemiology of Pediatric Severe Sepsis in Main PICU Centers in Southwest China
This multicenter study demonstrates that pediatric severe sepsis is common and is a factor in the high mortality rate that is observed in PICUs in Southwest China. The mortality rate remains high; therefore, improved... read more
The Invasion of the Physician Assistants
I was a senior emergency medicine resident at Darnall Army Community Hospital in Fort Hood, TX, in 1992. I wanted to do an elective rotation in anesthesia and to work closer to home because my wife and I lived 50 miles... read more
Thyroid Storm in the ICU
Thyroid storm requiring ICU admission causes high in-ICU mortality. Multiple organ failure and early cardiogenic shock seem to markedly impact the prognosis, suggesting a prompt identification and an aggressive management. 92... read more
1-Year Outcomes in Patients with Infection-related Atrial Fibrillation
During the first year after discharge, 36% of patients with infection-related atrial fibrillation (AF) had a new hospital contact with AF. Infection-related AF was associated with increased risk of thromboembolic events... read more
Intra-patient Potassium Variability After Hypothermic Cardiac Arrest
In a cohort of consecutive hypothermic cardiac arrest (CA) patients, we did not find an average difference in potassium concentration higher than 1 mmol/L between central and peripheral venous samples. However, we found... read more
Newer Drug Fails Quick Prehospital Intubation
Among patients undergoing endotracheal intubation in an out-of-hospital emergency setting, rocuronium, compared with succinylcholine, failed to demonstrate noninferiority with regard to first-attempt intubation success rate. Among... read more
Practical Transfusion Medicine
The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert hematologists,... read more
Machine Learning vs. Physicians’ Prediction of AKI in Critically Ill Adults
The machine-learning-based AKIpredictor achieved similar discriminative performance as physicians for prediction of AKI-23, and higher net benefit overall, because physicians overestimated the risk of AKI. This suggests... read more
Incidence of Dexmedetomidine Withdrawal in Adult Critically Ill Patients
The majority of patients in our study demonstrated signs that may be indicative of dexmedetomidine withdrawal. Peak and cumulative daily dexmedetomidine dose, rather than duration of therapy, may be associated with a higher... read more
Abnormalities in the Host Immune Response During Hospitalization for Sepsis
In this cohort study of 483 patients who survived hospitalization with sepsis at 12 US hospitals, 25.8% had elevated high-sensitivity C-reactive protein levels (a marker of inflammation) at 3 months, 30.2% at 6 months, and... read more
Delirium is Prevalent in Older Hospital Inpatients and Associated with Adverse Outcomes
Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The... read more
Failure of Non-invasive Ventilation in Patients with Acute Lung Injury
A high failure rate of the initial non-invasive positive pressure ventilation (NIPPV) therapy has been observed in medical critically ill patients with acute lung injury (ALI). Unless the underlying shock, metabolic acidosis... read more
Predicting Outcome in Patients with Moderate to Severe TBI Using Electroencephalography
Multifactorial Random Forest models using quantitative electroencephalography (qEEG) features, clinical data, and radiological findings have potential to predict neurological outcome in patients with moderate to severe traumatic... read more
