2019 Elf on the Shelf
It is time for the second annual Elf on the Shelf social media photo sweepstakes! Your creative entries help make the season bright. So, just snap a photo of an Elf on the Shelf scene in your unit, and submit it here. Three... read more
Assessment of Variability in End-of-Life Care Delivery in ICUs in the United States
This study suggests most decedents in the ICU avoid CPR at EOL, have family present at their bedside, and are closely assessed for pain. However, the delivery of EOL care varies widely among units in the United States, including... read more
Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children
The differences in total clearance (CLS) may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in... read more
Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications
A comprehensive review of the scientific and clinical studies that have led to the resurgence of interest in hypothermia as a neuroprotective strategy in the treatment of stroke and traumatic brain injury (TBI). Topics... read more
Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest
Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more
Climate Change, Global Warming, and Intensive Care
In the last five decades, human activities have resulted in the release of increasing quantities of carbon dioxide and other greenhouse gases, thus contributing to global climate change by additional heating of the atmosphere.... read more
Initial Therapy Affects Duration of Diarrhoea in Critically Ill Patients with Clostridioides Difficile Infection
Clostridioides Difficile Infection (CDI) further harms critically ill patients by increasing 28-day mortality and in case of prolonged diarrhoea the length of their hospital stay. Appropriate therapy should be initiated... read more
Tales From The Bedside: True Stories From A Night-Shift ICU Nurse
Tales From The Bedside is a collection of short stories from a caring and brilliant ICU nurse. Her stories will captivate you, make you laugh, warm your heart, shake your head, and just maybe... will inspire you, too. Step... read more
Patient and Family Member-Led Research in the ICU
Patient and family member-led research is a novel research approach that is feasible to conduct and can be used to identify opportunities for improving care. Study participants described shared key experiences in the... read more
Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol
The analyses described here are those necessary to answer the trial's primary question of whether combined treatment with vitamin C, thiamine and steroids is more effective than placebo in increasing days alive and free from... read more
Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells
Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red blood cells in reducing the risk of organ failure or death... read more
Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome
A serum ferritin level above 4420 ng/ml identifies in a reliable and very specific way the septic patient with macrophage activation-like syndrome (MALS). Since the recent subgroup analysis indicated a survival benefit... read more
Is Tranexamic Acid Going to CRASH the Management of TBI?
In the recent CRASH-3 randomized trial, early administration of tranexamic acid (TXA) was associated with a non-significant reduction of head injury-related 28-day mortality in patients with isolated traumatic brain injury... read more
The Oxygen Revolution: The Definitive Treatment of Traumatic Brain Injury (TBI) & Other Disorders
Hyperbaric oxygen therapy (HBOT) is based on a simple idea—that oxygen can be used therapeutically for a wide range of conditions where tissues have been damaged by oxygen deprivation. Inspiring and informative, The... read more
Vasopressin for Acute Hemorrhage?
Vasoactive medications are one of the pillars of management of shock in Emergency Departments. Inopressors, namely Norepinephrine and Epinephrine, are the two most commonly used pressors in US Emergency Departments, used... read more
Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury
Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers... read more
Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage
Critically ill patients with subarachnoid hemorrhage show a strong association between hyperchloremia and acute kidney injury as well as acute kidney injury and mortality. Of 1,267 patients included in this cohort, 16.7%... read more
Assessment of immune organ dysfunction in critical illness
Critical illness may often induce persisting injury-associated immunosuppression with adverse effects on relevant patient-centered outcomes. However, despite the key task of ICU physicians to detect, monitor, and follow up... read more
Predicting Adverse Hemodynamic Events in Critically Ill Patients
The art of predicting future hemodynamic instability in the critically ill has rapidly become a science with the advent of advanced analytical processed based on computer-driven machine learning techniques. How these... read more
The Protective Effects of Regional Hypothermia on Injured Limbs Combined with Hemorrhagic-shock & Tourniquet
The aim of this study is to investigate the protective effects of regional hypothermia (RH) on rabbits' limbs injured by a steel-ball combined with hemorrhagic-shock, and then employed tourniquet over-time, tried to identify... read more
Trauma Nursing: From Resuscitation Through Rehabilitation
Learn to provide state-of-the-art care to any patient in any setting with the most comprehensive trauma nursing resource available. Using the unique cycles of trauma framework, Trauma Nursing: From Resuscitation Through... read more
The Neurohormonal Basis of Pulmonary Hypertension in HFpEF
Subjects with heart failure with preserved ejection fraction (HFpEF) display activation of the endothelin and adrenomedullin neurohormonal pathways, the magnitude of which is associated with pulmonary hemodynamic derangements,... read more
