Temporal Trends in the Use of Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest
The use of therapeutic hypothermia decreased in a large US registry of patients with out-of-hospital cardiac arrest soon after the publication of a study supporting more lenient temperature thresholds. Concurrent with... read more
Anxiety, Depression and PTSD After Critical Illness
Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stress disorder... read more
Use of Vasopressor Increases the Risk of Mortality in Traumatic Hemorrhagic Shock
Use of vasopressor for traumatic hemorrhagic shock was associated with mortality after controlling for biases (trauma severity; volume of fluid resuscitation). Among 236,698 trauma patients, 3,551 were included in the... read more
Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis
In this meta-analysis of 37 RCTs (including 9564 patients), corticosteroid treatment was significantly associated with reduced 28-day mortality, ICU mortality, and in-hospital mortality among patients with sepsis. However,... read more
Lactate and Stepwise Lactate Kinetics Used to Guide Resuscitation
Lactate is an important parameter for monitoring tissue perfusion at present. Lactate kinetics are particularly important to evaluate the response of ICU patients. Therefore, lactate can be the starting point for resuscitation,... read more
Probiotics Linked to Bloodstream Infections in ICU Patients
People carry a community of microbes in and on our bodies, and they can have a powerful influence on our physiology in many ways. Probiotics, which are live microbes, are intended to improve human health, and they sometimes... read more
Pilot Study to Assess the Feasibility and Safety of Intermittent Enteral Feeding in Mechanically Ventilated Medical ICU Patients
With the advent of the feeding pump, default enteral nutrition schedules in many medical intensive care units has shifted from intermittent or bolus feeding to continuous feeds. Clinical studies suggest that each of these... read more
Intensivists’ Preferences for Patient Admission to ICU
ICU consultants vary in the importance they give to different factors in deciding who to prioritize for ICU admission. Transparency regarding which factors have been considered in the decision-making process could reduce... read more
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU
In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days. The number of ventilator-free... read more
Pediatric Critical Care Medicine: Care of the Critically Ill or Injured Child
The second edition of Pediatric Critical Care Medicine spans three volumes, with major sections dedicated to specific organ systems. Each major section consists of separate chapters dedicated to reviewing the specific... read more
Association Between Intravenous Contrast Media Exposure and Non-recovery From Dialysis-requiring Septic AKI
This large observational study did not support an association between intravenous contrast media and adverse in-hospital outcomes in patients with septic dialysis-requiring acute kidney injury (AKI-D). Further studies are... read more
Probiotics for the Prevention of Antibiotic-associated Diarrhea in Children
Antibiotic-associated diarrhea (AAD) occurs when antibiotics disturb the natural balance of "good" and "bad" bacteria in the intestinal tract causing harmful bacteria to multiply beyond their normal numbers. The symptoms... read more
Conditional Survival With Increasing Duration of ICU Admission
This is an observational study of three intensive care databases two in the United States (Medical Information Mart for Intensive Care III and electronic ICU) and one in United Kingdom (Post Intensive Care Risk-Adjusted Alerting... read more
Risk for Mortality in Critically Ill Children Needing RRT
Margaret M. Parker, MD, MCCM, speaks with Danny Hames, MD, on his article titled "Risk Factors for Mortality in Critically Ill Children Requiring Renal Replacement Therapy" published in the November 2019 issue of Pediatric... read more
Cardiogenic Shock – The Next Level & Mechanical Circulatory Support
We could center this discussion about the SCAI paper that came out (attached). A nice collaborative expert panel piece outlining a CS pyramid used quickly at the bedside in the ED, ICU, Cath Lab, etc to help us identify these... read more
Prophylactic Antibiotics After Cardiac Arrest?
This is a multicenter, double-blind, placebo-controlled trial of patients resuscitated from shockable out-of-hospital cardiac arrest. Patients were randomized to placebo versus intravenous amoxicillin-clavulanate for two... read more
Using Additional Pressure Control Lines When Connecting a Continuous RRT Device to an ECMO Circuit
The present study suggests that the use of additional tubing can be considered a simple and safe method for pressure control and improvement of filter survival when connecting a continuous renal replacement therapy (CRRT)... read more
Effect of Flexible Family Visitation on Delirium Among Patients in the ICU
In this cluster-crossover randomized clinical trial that involved 1,685 patients in the intensive care unit (ICU), the incidence of delirium was 18.9% in the flexible family visitation group compared with 20.1% in the standard... read more
Pilot Randomized Trial of a Recovery Navigator Program for Survivors of Critical Illness With Problematic Alcohol Use
A Recovery Navigator intervention was feasible and acceptable for delivering high-fidelity brief interventions to ICU patients. Changes in alcohol-related problems with motivational interviewing and shared decision-making... read more
Are Antibiotics for Sepsis in One Hour Feasible in the ED?
In this single-center study, implementation of sepsis protocols designed to expedite bundle delivery resulted in only a small fraction of patients receiving antibiotics within 1 hour of triage. This study validates the... read more
Ultrasound Assessment of Gastric Volume in Critically Ill Patients
Ultrasonographic measurement of antral CSA is feasible and reliable in the majority of critically ill patients. This technique could be useful to manage critically ill patients at risk of aspiration or with enteral feeding. Antral... read more
Competing and Conflicting Interests in the Care of Critically Ill Patients
Medical professionals are expected to prioritize patient interests, and most patients trust physicians to act in their best interest. However, a single patient is never a physician's sole concern. The competing interests... read more
