VAP Prevention in the ICU
Critically ill patients admitted to an intensive care unit for a life-threatening condition (both medical and surgical) can contract a ventilator-associated pneumonia (VAP). This is an infection acquired by virtue of... read more
Aspirin Reduces the Need for Mechanical Ventilation by Nearly Half For COVID-19 Patients
Patients hospitalized with COVID-19 and taking aspirin were nearly half as likely to require mechanical ventilation as those with COVID-19 not taking the drug, according to a study of adult patients. The patients were... read more
Association Between Comorbid COPD and Prognosis of Patients Admitted to ICU for Non-COPD Reasons
Comorbid COPD increased the risk of 28-day mortality among patients admitted to the ICU for non-COPD reasons, especially for those admitted to the cardiac surgery recovery unit. A retrospective cohort study was performed... read more
Risk Factors for Traumatic Intracranial Hemorrhage in Mild TBI Patients
The findings from this study provide additional context to risk factors currently in use as components in guidelines for the management of mild traumatic brain injury (mTBI) in the ED setting, contrasting high risk predictors... read more
Influenza-Complicated Thromboembolism in the ICU
Influenza-complicated thromboembolism (TE) among patients with severe influenza infection in the intensive care unit (ICU) is associated with increased risk for longer- duration mechanical ventilation, longer ICU stays, and... read more
Reducing Deep Sedation and Benzodiazepine Use in Mechanically Ventilated Patients During Critical Care Transport
The rate of deep sedation in this cohort was consistent with previously published data; however, it remains higher than clinically indicated. Over the course of the QI project, the proportion of deeply sedated patients... read more
Respiratory Effort in Mechanical Ventilation Weaning Prediction
This study demonstrates that PMI and ΔPocc are effective in predicting weaning outcomes in patients with DT≥2mm. The effectiveness of P0.1 in assessing weaning is also significantly higher in this subgroup. These findings... read more
Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy
In this randomized clinical trial of adults in the ICU with septic shock and severe endotheliopathy, infusion of iloprost, 1 ng/kg/min, for 72 hours did not reduce mean daily SOFA scores compared with placebo. In a clinical... read more
Human albumin solution for on-pump cardiac surgery: benefit or burden?
Deidentified individual participant data collected during the HAS FLAIR-II trial (and the data dictionary) will be shared beginning two years after article publication with no end date. These data will be available to... read more
Improving Patient Outcomes: Sepsis Protocols and Rapid Host Response Technologies
Patients come into the emergency department (ED) with symptoms, not diagnoses. That’s when time is of the essence. Clinicians must quickly triage patients and establish an appropriate care pathway to obtain the best possible... read more
Pediatric Critical Care: A Primer for All Clinicians
Pediatric critical care is an emotionally and intellectually demanding field of medicine; however, it is at its core the discipline focused on saving and improving the lives of children affected by acute and chronic illnesses,... read more
Resuscitation Arterial Waveform Quantification and Outcomes in Pediatric Patients
Providing physiologically adequate CPR for pediatric single ventricle patients palliated with Bidirectional Glenn (BDG) or Fontan physiology is challenging. Only 27% of Fontan patients survived to hospital discharge with... read more
Optimizing Oxygenation For Tracheal Intubation in Critically Ill Patients
Tracheal intubation (TI) is a common procedure frequently performed in critically ill patients and is an integral part of emergency airway management (EAM). However, it carries inherent risks and can significantly impact... read more
Sex Differences in the Outcome of Critically Ill COVID-19 Patients
Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females... read more
Feeding Challenges in the ICU
For critically ill patients, timely nutritional support can aid recovery and reduce mortality risk. But what about a patient in septic shock who is receiving vasopressor therapy, or one who requires prone positioning or extracorporeal... read more
Functional Dependence Following ICU-treated Sepsis
Sepsis survivorship was associated with a broad range of new impairments and led to functional dependence in around one quarter of patients. Targeted measures are needed to mitigate the burden of this Post-Sepsis-Syndrome... read more
Veno-Arterial-Venous ECMO in a Patient Undergoing Dialysis and Having Cardiopulmonary Failure Due to COVID-19
COVID-19 can cause cardiomyopathy, a rare cardiovascular disorder that can lead to cardiogenic shock. The cardiac and respiratory symptoms may not occur simultaneously, and it is possible to switch to veno-arterial-venous... read more
Adiposity and Mortality Among ICU Patients with COVID-19 and Non-COVID-19 Respiratory Conditions
Obesity is associated with higher mortality among COVID-19 patients, but lower mortality among non-COVID-19 respiratory patients. These associations appear vulnerable to confounding/selection bias in both patient groups,... read more
Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients
In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early... read more
Army Scientists’ Technique for Early Sepsis Detection in Burn Patients Submitted to FDA
A new invention developed at the U.S. Army Medical Research and Development Command uses an artificial intelligence machine learning algorithm to identify whether burn patients are at risk of experiencing life-threatening... read more
Early sodium bicarbonate therapy for critically ill patients with septic shock and acute moderate metabolic acidosis
In recent decades, septic shock has continued to be a life-threatening health problem around the world. Meanwhile, metabolic acidosis (MA) is also well known in critically ill patients, and even moderate metabolic acidosis... read more
Outcomes of ECMO in ARDS in Pediatric Trauma Patients
Among children who suffer from acute respiratory distress syndrome (ARDS) complications following trauma, the use of extracorporeal membrane oxygenation (ECMO) failed to show any association with mortality benefit. More... read more
