Oxygen Therapy in Acute Hypoxemic Respiratory Failure

Although largely used, the place of oxygen therapy and its devices in patients with acute hypoxemic respiratory failure (ARF) deserves to be clarified. The French Intensive Care Society (Société de Réanimation de Langue... read more

Conservative or Liberal Oxygen Targets in Patients on VA-ECMO

In adults receiving VA-ECMO in the ICU, a conservative compared to a liberal oxygen strategy did not affect the number of ICU-free days to day 28, nor any other measurable patient outcomes up to 6 months after ICU admission.... read more

Long-term Outcomes in Nutrition Trials

Survivors of critical illness frequently suffer from physical, cognitive and mental disorders after hospital discharge, leading to increased disabilities, poor quality of life, and worse long-term outcomes. Therefore,... read more

Predictive Biomarkers of Mortality in ICU Patients with Severe COVID-19

This study shows changes in hematological, biochemical, and inflammatory parameters in COVID-19 non-surviving patients. Lymphopenia, neutrophilia, and thrombocytopenia, as well as increased levels of CRP, AST, creatinine,... read more

Nitric Oxide Inhibitors Changes and Mortality in Critically Ill Patients

Increasing asymmetric dimethylarginine (ADMA) concentrations on days 1-3 are inversely associated with mortality, however not with the same strength as high ADMA or SDMA concentrations at admission. We suggest that admission... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

Low-Frequency Ventilation May Facilitate Weaning in ARDS Treated with ECMO

Low-frequency ventilation is comparable to conventional protective ventilation in patients with ARDS who have been treated with ECMO. However, low-frequency ventilation may support weaning from invasive mechanical ventilation... read more

A prediction model for nonresponsive outcomes in critically ill patients with ARDS undergoing prone position ventilation

In this study, a risk prediction model for nonresponse to prone position ventilation in acute respiratory distress syndrome (ARDS) patients was constructed, which demonstrated good predictive value and clinical utility. Early... read more

Predictors of High-flow Nasal Cannula Failure in COVID-19 Patients

A retrospective cohort study was conducted during the months of March and May 2021. Data collection was based on a follow-up of 156 hospitalized patients with a diagnosis of COVID-19 who were users of high-flow nasal cannula... read more

Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients

A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more

Troponin Role in the Diagnosis and Treatment of Acute Pulmonary Embolism

Acute pulmonary embolism (APE) is a cardiovascular disease with severe consequences, wherein cardiac troponin (Tn) plays a pivotal role in diagnosis and treatment. This article reviews the various roles of Tn in managing... read more

Influenza and COVID-19 Vaccination Rates Among Children Receiving Long-Term Ventilation

Children with tracheostomy and HV are at high risk of morbidity and mortality from viral ARIs. Among MyTRaCh enrollees, we found significant discrepancy between influenza and COVID-19 vaccination status. Compared with... read more

Early Invasive Strategy Impact on Left Ventricular Function Recovery in Acute Myocardial Infarction Patients

This study underscores the significant benefits of early invasive strategies in improving left ventricular function recovery and reducing adverse outcomes in acute myocardial infarction patients in Pakistan. The findings... read more

Non-invasive vs. Arterial Pressure Monitoring in the Pre-hospital Critical Care Environment

Non-invasive blood pressure measurements are often inaccurate within the pre-hospital critical care setting, particularly in patients with hemodynamic instability which are the group in which the accuracy of vital signs is... read more

Antithrombin III Levels and Outcomes Among Patients With Trauma

In this cohort study of trauma patients, antithrombin III deficiency was associated with greater severity of illness and worse hospital outcomes. Specifically, antithrombin III deficiency was associated with fewer ventilator-free... read more

Critical Care Device Series: External Ventricular Drain

External ventricular drainage (EVD), is one of the most frequently performed neurosurgical procedures, with approximately 20,000 performed annually. EVD placement is often considered a lifesaving measure to alleviate severe... read more

Hyperoxemia in Acute Trauma is Common and Associated with a Longer Hospital Stay

This study indicate that hyperoxemia is not associated with increased 28-day mortality compared to normoxemia. Nonetheless, both moderate and severe hyperoxemia are frequently detected in trauma patients, with severe hyperoxemia... read more

How does high fowlers position help with ventilation?

The High Fowler's position, characterized by an inclination of 60-90 degrees, significantly enhances ventilation by optimizing lung expansion and improving respiratory mechanics. This position is particularly beneficial for... read more

Longitudinal Changes in Emergency Medical Services Advanced Airway Management

Our cross-sectional study offers important contemporary perspectives of the current patterns of EMS advanced airway management in the US. Using the large ESO dataset, which encompasses EMS events from across the US, we observed... read more

Sepsis Mortality Prediction in ICU Patients Using Machine Learning

This study has achieved significant advancements in predicting sepsis outcomes by utilizing advanced machine learning techniques and sophisticated data preprocessing methods. These methods include data grouping and effective... read more

Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension

Fluid administration is the first line treatment in intensive care unit (ICU) patients with sepsis and septic shock. While fluid boluses administration can be titrated by predicting preload dependency, the amount of other... read more

Longitudinal Vasoactive Inotrope Score Trajectories and Their Prognostic Significance in Critically Ill Sepsis Patients

This study offers significant insights into the prognostic value of VIS trajectories in sepsis patients. The identification of distinct trajectory patterns not only underscores the heterogeneity in sepsis but also emphasizes... read more