Antithrombin III Levels and Outcomes Among Patients With Trauma
In this cohort study of trauma patients, antithrombin III deficiency was associated with greater severity of illness and worse hospital outcomes. Specifically, antithrombin III deficiency was associated with fewer ventilator-free... read more
Critical Care Device Series: External Ventricular Drain
External ventricular drainage (EVD), is one of the most frequently performed neurosurgical procedures, with approximately 20,000 performed annually. EVD placement is often considered a lifesaving measure to alleviate severe... read more
Hyperoxemia in Acute Trauma is Common and Associated with a Longer Hospital Stay
This study indicate that hyperoxemia is not associated with increased 28-day mortality compared to normoxemia. Nonetheless, both moderate and severe hyperoxemia are frequently detected in trauma patients, with severe hyperoxemia... read more
How does high fowlers position help with ventilation?
The High Fowler's position, characterized by an inclination of 60-90 degrees, significantly enhances ventilation by optimizing lung expansion and improving respiratory mechanics. This position is particularly beneficial for... read more
Longitudinal Changes in Emergency Medical Services Advanced Airway Management
Our cross-sectional study offers important contemporary perspectives of the current patterns of EMS advanced airway management in the US. Using the large ESO dataset, which encompasses EMS events from across the US, we observed... read more
Sepsis Mortality Prediction in ICU Patients Using Machine Learning
This study has achieved significant advancements in predicting sepsis outcomes by utilizing advanced machine learning techniques and sophisticated data preprocessing methods. These methods include data grouping and effective... read more
Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension
Fluid administration is the first line treatment in intensive care unit (ICU) patients with sepsis and septic shock. While fluid boluses administration can be titrated by predicting preload dependency, the amount of other... read more
Longitudinal Vasoactive Inotrope Score Trajectories and Their Prognostic Significance in Critically Ill Sepsis Patients
This study offers significant insights into the prognostic value of VIS trajectories in sepsis patients. The identification of distinct trajectory patterns not only underscores the heterogeneity in sepsis but also emphasizes... read more
COVID-19 ARDS Patients vs. Patients with ARDS
Ventilation management may differ between COVID–19 ARDS (COVID–ARDS) patients and patients with pre–COVID ARDS (CLASSIC–ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC–ARDS... read more
Early Reapplication of Prone Position During VV-ECMO for ARDS
A combination of prone positioning (PP) and venovenous extracorporeal membrane oxygenation (VV-ECMO) is safe, feasible, and associated with potentially improved survival for severe acute respiratory distress syndrome (ARDS).... read more
Tracheal Intubation in Critically Ill Adults with a Physiologically Difficult Airway
Using a Delphi method, agreement among a panel of international experts was reached for 53 statements providing guidance to clinicians worldwide on safe tracheal intubation practices in patients with a physiologically difficult... read more
Effect of Different Shock Conditions on Mesenteric Hemodynamics
The velocity parameters of SMA Doppler ultrasound such as TAMV and PSV can reflect cardiac function. The measurements of SMA RI and PI are correlated with lactate levels, having a positive predictive value for hyperlactatemia... read more
Outcomes of Different Steroid Dosing Regimens in Critical Covid-19 Pneumonia
The study found that high-dose steroids in the treatment of critically ill patients with COVID-19 pneumonia did not confer any mortality benefit and were associated with an increased risk of dysglycemia and superimposed infections. A... read more
Factors Affecting the Duration of Hospitalization in Urology and Nephrology Patients in the ICU
Factors affecting ICU stay length in Urology and Nephrology patients who required close monitoring and specialized medical staff were investigated. The study found a positive association between prolonged ICU stays and elevated... read more
Glucose Metabolism Disorders: Pre-hospital Oxygen Therapy and Saturation Variability in COVID-19 Patients
The COVID-19 pandemic has revealed that viruses can have multiple receptor properties, penetrating various tissues and causing mutations in various genes, thus promoting a range of metabolic disorders. The purpose of... read more
Ventilator-associated Pneumonia Risk Factors in Patients with Severe COVID-19
Patients with COVID-19 are at high risk of VAP, which may be related to issues other than prolonged mechanical ventilation (MV) time. Multiple factors increase the chances of these patients developing VAP, including:... read more
Noninvasive Monitoring of Changes in Cerebral Hemodynamics During Prolonged Field Care for Hemorrhagic Shock and Hypoxia-Induced Injuries With Portable Diffuse Optical Sensors
There is a consistency in blood flow measures in both injury mechanisms (hemorrhagic shock and hypoxia), which is significant as the new prototype system provides similar measures and trends for each brain injury type, suggesting... read more
Core Concepts in Acute Kidney Injury
This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis... read more
Endothelial Activation and Microcirculatory Disorders in Sepsis and Critical Illness
The endothelium is one of the largest organs in the human body and lines the blood vessels and microcirculation of all the vital organs. As such, it functions as a massive and critical surveillance system to orchestrate recognition... read more
Ultrafast Cooling With Total Liquid Ventilation Mitigates Early Inflammatory Response
Ultrafast cooling with TLV mitigates neuroinflammation and attenuates acute brain lesions in the early phase following resuscitation in large animals subjected to cardiac arrest (CA). Brain injury is one of the most serious... read more
Pitfalls in the Management of Mechanical Ventilation: ARDS and Hypermetabolic States
Mechanical Ventilation (MV) is an invaluable, lifesaving therapy for patients with acute respiratory failure, but it must be individualized for each specific underlying physiologic derangement to maximize benefits and minimize... read more
Prevalence and Risk Factors of ICU-acquired Weakness in COVID-19 Patients
The prevalence of ICUAW in patients with COVID-19 was considered relatively high. Older age, pre-existing hypertension, medical intervention of prone position, NMBA use, needed tracheostomy and RRT were likely risk factors.... read more
