Genetic Testing in Early-onset Atrial Fibrillation
Atrial fibrillation (AF) is a globally prevalent cardiac arrhythmia with significant genetic underpinnings, as highlighted by recent large-scale genetic studies. A prominent clinical and genetic overlap exists between... read more
EKG/ECG Interpretation Made Easy
In this guide, you will understand how ECGs are performed, what they represent about the heart, and what it means to see something you don't think is normal. Before you get into the hard stuff—the actual interpretation... read more
Trauma Medical Home: New Coordinated Care Model for Injured Older Adults
Older adults who suffer serious injuries from a fall or a motor vehicle accident often have impaired long-term functioning and diminished quality of life. A new study, published in JAMA Surgery by researcher-clinicians... read more
Treatment of Refractory Cardiac Arrest by Controlled Reperfusion of the Whole Body
This multicenter, prospective, all-comers observational study has provided preliminary data on a new approach to treat patients with prolonged refractory CA and CCPR by applying an advanced extracorporeal perfusion circuit,... read more
Antifungal Prophylaxis of COVID-19 Associated Pulmonary Aspergillosis in Ventilated Patients
This study investigated the impact of POSA prophylaxis on risk of CAPA development in mechanically ventilated COVID-19 patients receiving corticosteroids. We observed a significant variation in CAPA incidence rates among... read more
High-flow Nasal Cannula Oxygen vs. NIV in AHF-related ARF
In this pilot study, we did not observe a statistically significant difference in changes in respiratory rate among patients with acute respiratory failure (ARF) due to acute heart failure (AHF) and managed with high-flow... read more
Another Perspective on Tidal Volume: From Statistics to Uncertainty
We have read with great interest the recent editorial by Pellegrini et al. Undoubtedly, now more than ever, we have begun to question the true role of tidal volume (VT) in acute respiratory distress syndrome (ARDS). As... read more
Vasoconstriction in Septic Shock
Septic shock is associated with endothelial dysfunction leading to arterial and venous dilation, alterations in regional blood flow distribution, and microcirculatory disturbances. Fluids and vasopressors are the key... read more
Secretomic Approach Value in COVID-19 Viral Pneumonia Among Patients With Respiratory Distress
this article presents an innovative and promising secretomic analysis to distinguish VPP patients from NV-ICU patients using combinations of protein markers. Among the identified proteins, ficolin-3 and proteoglycan-4 appear... read more
Prevalence and Survival of Prolonged VV ECMO for ARDS
The understanding of prolonged venovenous extracorporeal membrane oxygenation (VV ECMO) in the setting of acute respiratory distress syndrome (ARDS) is evolving and durations of support once considered extreme are now commonplace.... read more
PEEP May Cause Harm in Less Severe ARDS
A higher positive end-expiratory pressure (PEEP) strategy may cause harm in adult patients with acute respiratory distress syndrome (ARDS) whose subphenotype is characterized by less inflammation and lower severity of illness. The... read more
Critical Care Companion: Your Guide To ICU Nursing
Step into the dynamic and demanding world of Intensive Care Unit (ICU) nursing with Critical Care Companion: Your Guide to ICU Nursing by Alysha Edwards. This indispensable guide is crafted to support both novice and experienced... read more
The Existence of Adrenal Insufficiency in COVID-19 Patients with Pneumonia
Patients with a history of COVID-19 pneumonia who present with clinical symptoms such as shock, nausea, vomiting, and fatigue should have hypocortisolism included in the differential diagnosis. These patients should also... read more
COVID-19 Infections Are Growing
Large areas of the US are experiencing a significant spread of COVID-19, with the pandemic reaching alarming levels. Data from the Centers for Disease Control and Prevention indicates that the spread of the disease has officially... read more
Ketones Alleviates COVID-19-related ARDS
In this randomized controlled trial, supplementation with beta-hydroxybutyrate improved inflammatory biomarkers and reduced the length of hospitalization in adults with COVID-19–related acute respiratory distress syndrome... read more
Dexamethasone Systemic Effects in Severe COVID-19
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk... read more
Emergency Department Disposition and Mortality in COVID‐19 Patients with ARDS
Compared to direct ICU admission, admission from the ED to the ward is associated with increased mortality in patients who meet COVID‐19 ARDS criteria during their hospitalization, despite lower 4C and similar SAPS‐III... read more
Endothelial Dysfunction and Persistent Inflammation in Severe Post-COVID-19 Patients
Six months after ICU discharge from severe ARDS secondary to COVID-19, patients with gas exchange impairment exhibit evidence of systemic inflammation, along with elevated ICAM-1 levels, ultimately resulting in increased... read more
BARDA Selected Host-directed Therapeutic Candidates to Address ARDS
Biomedical Advanced Research and Development Authority (BARDA) has selected host-directed therapeutic candidates for inclusion in a phase 2 platform clinical trial to address acute respiratory distress syndrome (ARDS). Currently,... read more
Cardiac Arrest During a Ferric Derisomaltose Infusion Followed by Complete Heart Block
Bradycardia and heart block are rarely reported in the parenteral iron literature. Although rare, it may be reasonable to consider parenteral iron as a toxicological etiology for patients presenting with complete heart block... read more
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS
The extended lung protection with strict control of ΔP for moderate to severe ARDS plus deranged mechanics is feasible and could be implemented in this pilot study with some beneficial impact on the recovery of lung function.... read more
Weaning From Mechanical Ventilation in ICUs Across 50 Countries
Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients... read more
