Trauma ICU Rounds – The rEVOLUTION of ECMO
What are the indications for ECMO beyond ARDS and refractory cardiogenic shock? In which patients should we consider eCPR and is this the new standard of care for patients sustaining out-of-hospital cardiac arrest? Finally,... read more
Mortality Among LVAD Recipients Ineligible for Clinical Trials
These findings suggest that while treatment for patients who are ineligible for left ventricular assist device (LVAD) trial inclusion should be weighed against medical management, more consideration could be given to designing... read more
Problems in care and avoidability of death after discharge from ICU
The proportion of deaths in hospital with some degree of avoidability is higher in patients discharged from an ICU than reported in hospital-wide populations. Extrapolating our findings suggests around 550 probably avoidable... read more
Risk Factors of Ischemic and Hemorrhagic Strokes During Venovenous ECMO
Among venovenous extracorporeal membrane oxygenation patients in the Extracorporeal Life Support Organization registry, approximately 5% had acute brain injury. Mortality rates increased two-fold when ischemic or hemorrhagic... read more
Cost-effectiveness of Adrenaline for Out-of-Hospital Cardiac Arrest
Adrenaline was not cost-effective when only directly related costs and consequences are considered. However, incorporating the indirect economic effects associated with transplanted organs substantially alters cost-effectiveness,... read more
Neutrophilic Inflammation, Immunothrombosis May Distinguish Severe COVID-19 From Influenza
Severe coronavirus disease 2019 (COVID-19) is associated with immunothrombotic, neutrophil-containing vessel occlusions in the lung, with neutrophils representing the primary immune cell component associated with clinical... read more
The Value of Decreasing the Duration of the Infectious Period of Severe ARDS COVID-19 Infection
Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could potentially reduce transmission in the broader population. We developed a computational... read more
A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion
Ex vivo lung perfusion (EVLP) is increasingly used to treat and assess lungs before transplant. Minimizing ventilator induced lung injury (VILI) during EVLP is an important clinical need, and negative pressure ventilation... read more
Management of late onset urea cycle disorders-a remaining challenge for the intensivist?
Awareness of urea cycle disorders in adults intensive care units can optimize early management and accordingly dramatically improve prognosis. By preventing hyperammonemia to induce brain edema and herniation leading to death. Hyperammonemia... read more
Estimate Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation Using Doppler Echocardiography
In mechanically ventilated critically ill patients, Doppler transthoracic echocardiography indices are highly specific but not sensitive to estimate pulmonary artery occlusion pressure. Transmitral early velocity wave... read more
Inadvertent direct pulmonary artery catheterization complicating the effort for subclavian venous cannulation and central venous catheter placement
Subclavian access is commonly used in the intensive care unit (ICU) for central venous catheterization. Many complications have been reported during the placement of central venous catheters including pneumothorax, hemothorax,... read more
Allergic Reactions After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine
Early safety monitoring of the Pfizer-BioNTech COVID-19 vaccine has detected 21 cases of anaphylaxis after reported administration of 1,893,360 first doses of Pfizer-BioNTech COVID-19 vaccine (11.1 cases per million vaccine... read more
Allergic Reactions to COVID-19 Vaccine
To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with no serious concerns identified in the ongoing... read more
How to be EPIC in the COVID-19 Era
Evolution is afoot. It's entirely possible you have noticed somewhat of an alteration in the world around us. A pandemic—the downwind effect of a miniscule strand of RNA and its lollipop-studded shell, a savage little virus... read more
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
The mRNA-1273 vaccine showed 94.1% efficacy at preventing COVID-19 illness, including severe disease. Aside from transient local and systemic reactions, no safety concerns were identified. The trial enrolled 30,420 volunteers... read more
The Risk of False Negative Results with the Curative COVID-19 Test
The U.S. Food and Drug Administration (FDA) is alerting patients and health care providers of the risk of false results, particularly false negative results, with the Curative SARS-Cov-2 test. Risks to a patient of a... read more
FDA Warns Against Cutting the COVID-19 Vaccine Dosing in Half
The Food and Drug Administration (FDA) is warning health care workers that any changes to the authorized dosing schedules of COVID-19 vaccines currently being administered would significantly place public health at risk and... read more
Understanding Moral Injury
The Understanding Moral Injury video was put together by the LTLC-Critical Care programme. This is an HEE and NHSEI initiative aimed at supporting the cross-skilling of the London NHS workforce to manage existing and spikes... read more
The Evolving Armamentarium of COVID-19 Therapeutics
Multiple repositories have been created for the vast scientific outpouring of COVID-19 research. The NIH regularly updates its treatment guidelines, which will be the primary reference for this review. To cut to the... read more
Unexpectedly High Frequency of Enterococcal Bloodstream Infections in COVID-19 Patients Admitted to an Italian ICU
Coronavirus disease 2019 seemed to increase the frequency of bloodstream infections (particularly Enterococcus-related bloodstream infection) after ICU admission. This may have been due to enteric involvement in patients... read more
Ivermectin for COVID-19, Breakthrough Treatment or Hydroxychloroquine Redux?
It’s an indisputable fact that we need better treatments for COVID-19. This is particularly true in the outpatient setting. Let’s count how many we have today, hmm, this shouldn’t take long. That would be zero —... read more
How I Prescribe CRRT
Continuous renal replacement therapy (CRRT) delivers gradual clearance of solutes, fluid balance control, and haemodynamic stability. CRRT does not appear to increase survival compared to intermittent renal replacement therapy... read more
