Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery

A FF strategy was not associated with changes to early enteral nutrition delivery. Inflammation, insulin resistance, and morbidity were similar, but FF may modify the relationship between inflammation and adverse event. Multicenter... read more

Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery

Dexmedetomidine for Prolonged Sedation in the PICU

High-quality data on dexmedetomidine use for prolonged sedation and a consensus on correct dosing and weaning protocols in children are currently missing. Infusion of dexmedetomidine can be considered relatively safe in pediatrics... read more

Dexmedetomidine for Prolonged Sedation in the PICU

Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events

Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted... read more

Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events

The Impact on Pediatric Emergency Care during COVID-19

Although most children with COVID-19 are asymptomatic or present with mild disease, serious—but rare—complications are being seen in pediatric patients. This supplement describes the epidemiology, clinical features, and... read more

The Impact on Pediatric Emergency Care during COVID-19

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

In this case series of hospitalized children who met criteria for PIMS-TS, there was a wide spectrum of presenting signs and symptoms and disease severity, ranging from fever and inflammation to myocardial injury, shock,... read more

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Pediatric Airway Management in COVID-19 Patients

The severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has challenged medical systems and clinicians globally to unforeseen levels. COVID-19's rapid spread has forced clinicians to care for patients with... read more

Pediatric Airway Management in COVID-19 Patients

Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients

These results demonstrate that intranasally (IN) dexmedetomidine is relatively rapidly absorbed and causes significant sedation in pediatric patients. Pharmacokinetics of IN dexmedetomidine in pediatric patients show quite... read more

Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients

New Technology Gives Parents Virtual Face Time With Their Hospitalized Children

The pediatric intensive care unit (PICU) team at the University of Maryland Children's Hospital (UMCH) is offering a new way for families to interact with their child and the medical team when they can’t be there in person. PICU... read more

New Technology Gives Parents Virtual Face Time With Their Hospitalized Children

Life Following Pediatric Septic Shock

Margaret M. Parker, MD, MCCM, and Jerry J. Zimmerman, MD, PhD, FCCM, talk about the trajectory of long-term mortality and significant health-related quality of life disability among children encountering septic shock. This... read more

Life Following Pediatric Septic Shock

Echocardiography in Pediatric and Congenital Heart Disease

This comprehensive textbook on the echocardiographic assessment of pediatric and congenital heart disease has been updated for a second edition with an emphasis on new technologies. This highly-illustrated full-color reference... read more

Echocardiography in Pediatric and Congenital Heart Disease

Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence... read more

Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality) compared with standard-issue red blood... read more

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Neonatal Lung Ultrasonography

This book presents lung ultrasound as an accurate, reliable, low-cost and simple imaging technique, which poses no risk of radiation damage, making bedside use both feasible and convenient in neonatal wards. The aim of... read more

Neonatal Lung Ultrasonography

Depth of Anesthesia in Children Undergoing Cardiac Surgery Under Extracorporeal Circulation

In children undergoing cardiac surgery in our department, the use of sevoflurane-balanced anesthesia during cardiopulmonary bypass showed no superiority of inhalational agents over total intravenous anesthesia with opioids... read more

Depth of Anesthesia in Children Undergoing Cardiac Surgery Under Extracorporeal Circulation

Holding Intubated Infants Well Tolerated and Safe

Critically ill infants who are old enough to move on their own but too young to cooperate with care instructions have been among the last to benefit from patient mobility initiatives. Results from a holding intervention... read more

Holding Intubated Infants Well Tolerated and Safe

Serum Protein Changes in Pediatric Sepsis Patients Identified with an Aptamer-Based Multiplexed Proteomic Approach

The serum protein changes identified with the aptamer-based multiplexed proteomics approach used in this study can be useful to distinguish between sepsis and noninfectious systemic inflammation. A cohort of 40 children... read more

Serum Protein Changes in Pediatric Sepsis Patients Identified with an Aptamer-Based Multiplexed Proteomic Approach

Optimal Duration of Mechanical Ventilation and Influencing Factors Following Mandibular Distraction Osteogenesis in Infants

Mandibular distraction osteogenesis (MDO) is an effective treatment for tongue-based airway obstruction in infants with severe Pierre Robin sequence (PRS). Most infants receiving MDO require postoperative mechanical ventilation... read more

Optimal Duration of Mechanical Ventilation and Influencing Factors Following Mandibular Distraction Osteogenesis in Infants

Fully Automated, Real-time, Calibration-free, Continuous Noninvasive Estimation of Intracranial Pressure in Children

This nICP estimation algorithm, based on arterial blood pressure (ABP) and bedside transcranial Doppler (TCD) cerebral blood flow velocity (CBFV) waveform measurements, performs in a manner comparable to invasive intracranial... read more

Fully Automated, Real-time, Calibration-free, Continuous Noninvasive Estimation of Intracranial Pressure in Children