Tag: study
COVID-19: Limitation of Life-sustaining Treatment and Patient Involvement in Decision-making
Life-sustaining treatment limitation decisions were made for 18% of a COVID-19 patient cohort. Hereof, more than a third of the decisions had been made before hospital admission. Many records lacked information on patient... read more
UK 28-Day Mortality Trends of COVID-19 Patients
There was a marked deterioration in outcomes for patients admitted to critical care at the peak of the second wave of coronavirus disease 2019 in United Kingdom (December 2020–January 2021), compared with the post-first-wave... read more
Cancer Clues In A Drop Of Blood
New diagnostic blood test paves the way for early stage lung cancer screening. A diagnostic blood test may provide early detection of lung cancer in asymptomatic patients, according to a new study. Lung cancer, the leading... read more
Rapid Screening of Critically Ill Patients for Low Plasma Vitamin C Concentrations Using sORP
Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The static oxidation... read more
The Obesity Paradox in Critically Ill Patients
A causal inference approach that is robust to residual confounding bias due to model misspecification and selection bias due to missing (at random) data mitigates the obesity paradox observed in critically ill patients, whereas... read more
Effect of High vs. Low Dose of Dexamethasone on COVID-19 Pneumonia Patients
Among hospitalised COVID-19 patients needing oxygen therapy, high dose of dexamethasone reduced clinical worsening within 11 days after randomisation as compared with low dose of dexamethasone. Further studies are necessary... read more
Intubation Practice and Outcomes Among Pediatric Emergency Departments
While tracheal intubation (TI) characteristics vary between pediatric Emergency Departments and ICUs, outcomes are similar. Shock and limited mouth opening were independently associated with adverse TI events in the Emergency... read more
Obesity, Inflammatory and Thrombotic Markers, and Major Clinical Outcomes in Critically Ill Patients with COVID-19 in the US
In critically ill patients with COVID-19, higher BMI was not associated with death or thrombotic events but was associated with a greater risk of ARDS and AKI-RRT. The lack of an association between BMI and circulating... read more
Feasibility of Conservative Fluid Administration and Deresuscitation vs. Usual Care
A strategy of conservative fluid administration and active deresuscitation is feasible, reduces fluid balance compared with usual care, and may cause benefit or harm. In view of wide variations in contemporary clinical... read more
Neurological Outcomes in Patients with OHCA who received ECPR
Little is known about the difference in outcomes between young and old patients who received extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA). Therefore, we aimed to investigate... read more
Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise
Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality... read more
Outcomes of Catheter-Related Arterial and Venous Thrombosis After Enoxaparin Therapy in Neonates and Infants With Congenital Heart Disease
A high proportion of vascular catheter-related thrombi identified in infants with congenital heart disease resolve with enoxaparin treatment. In all patients with thrombosis, arterial versus venous thrombosis is associated... read more
The Effect of Lowering Tidal Volume on Mortality
The use of low tidal volume (4-8 ml/kg of predicted body weight) has been considered the default way to ventilate patients with acute respiratory distress syndrome (ARDS) to minimize ventilator-induced lung injury (VILI).... read more
Intravenous Push Levetiracetam Safety in a Neuro-Spine ICU
Administration of levetiracetam doses up to 2000 mg via IVP is a safe method of administration that results in a reduction of time to medication administration and a reduction of benzodiazepine use. Of the 2,055 hospital-wide... read more
Alterations in qSOFA, SIRS, MEWS or NEWS Score Present in Half of Patients
Almost half of patients with a suspected infection experience a change in the score of qSOFA, SIRS, MEWS and/or NEWS during ED stay. Approximately half of alterations were from a normal to an abnormal score and half vice... read more
Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis
The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more
First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy
Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more
Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols... read more
Noninvasive Ventilation and Outcomes in Bronchiolitis
In a large cohort of infants at children’s hospitals, noninvasive and invasive ventilation increased significantly from 2010 to 2018. Hospital-level noninvasive ventilation utilization was not associated with a reduction... read more
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more
Burden of Post-Sepsis Morbidity Higher Than Previously Thought
A recent cohort study published in JAMA based on data from 116,507 survivors of hospital-treated sepsis in Germany sheds light on the heavy burden of long-term effects of sepsis, the most severe complication of infections. The... read more
Recovery, Rehabilitation and Follow-up Services After Critical Illness
Overall, these data demonstrate a proliferation of recovery, follow-up and rehabilitation services for critically ill adults in the past decade across the UK, although service gaps remain suggesting further work is required... read more
