Tag: study
Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
COVID-19 is an infectious respiratory disease caused by a coronavirus called SARS-CoV-2. If the infection becomes severe, people may need intensive care and support in hospital, including mechanical ventilation. Drugs... read more
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients
Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how rapidly this response occurs, or when antibodies with protective capability evolve.... read more
RECOVERY trial shows tocilizumab reduces deaths in patients hospitalised with COVID-19
The NIHR-supported RECOVERY trial has shown that tocilizumab - an anti-inflammatory rheumatoid arthritis treatment - reduces the risk of death for hospitalised patients with severe COVID-19. Researchers also found that... read more
Safety of RSI in an Emergency Training Network
Implementation of an evidence-based care bundle and audit of practice has created a safe environment for trainees to learn the core critical care skill of Rapid sequence intubation (RSI). In our setting, checklist use was... read more
Resident competencies before and after short ICU rotations
A monthly multi-competency assessment for specialty residents rotating in the ICU is likely feasible for most programs with appropriate resources, and generally acceptable for residents. Specialty residents' cognitive reasoning... read more
COVID-19 Awake Proning – All Hype?
In this prospective meta-analysis of observational studies of patients with acute hypoxemic respiratory failure due to COVID-19, APP did not result in lower intubation or mortality rates, despite reported improvements in... read more
Mediastinal lymphadenopathy may predict 30-day mortality in COVID-19 patients
Along with older age and consolidation pattern,enlarged mediastinal lymphadenopathy was found to be an independent predictor of 30-day mortality in patients with COVID-19. Although enlarged mediastinal lymphadenopathy... read more
Prediction Model for Severe CAP among Patients with Diabetes Mellitus
Diabetes is an independent risk factor for the development of severe community-acquired pneumonia (CAP) and associated with pneumonia-related hospitalization as well as mortality. Here, we assessed several selected biomarkers... read more
COVID-19: Clinical manifestations of blood cell parameters and inflammatory factors
CRP and Lymphocyte count (LYM#) showed strong correlation with disease progression, suggesting that these parameters could be used to monitor changes in patient condition. 92 patients with confirmed COVID-19 at Jingzhou... read more
Pharyngeal abscess: a rare complication of repeated nasopharyngeal swabs
A 73-year-old end-stage renal disease patient who had undergone craniopharyngioma resection 30 years previously was admitted to hospital after a fall. He developed hospital-acquired laboratory-confirmed SARS-CoV-2 that required... read more
Association between perioperative fluid administration and postoperative outcomes
Irrespectively to the amount of perioperative fluid administered, goal-directed therapy (GDT) strategy reduces postoperative complications, but not perioperative mortality. The metanalysis included 21 RCTs enrolling 2,729... read more
Opioid Use After Intensive Care
Mean opioid consumption is increased 24 months after ICU admission despite the lack of evidence for long-term opioid treatment. Given the high number of ICU entries and risk of excess mortality for chronic users, preventing... read more
Association between the BMI and outcomes of patients resuscitated from OHCA
The body mass index (BMI) was not independently associated with favourable neurologic and survival outcomes of patients surviving from out-of-hospital cardiac arrest (OHCA). Nine hospitals were enrolled; finally, 605 patients... read more
Janssen Investigational COVID-19 Vaccine
An investigational COVID-19 vaccine developed by Janssen Pharmaceuticals appears to be safe and effective at preventing moderate and severe COVID-19 in adults, according to an interim analysis of Phase 3 clinical data conducted... read more
Contrast-enhanced Ultrasound (CEUS) of the Lung Reveals Multiple Areas of Microthrombi in a COVID-19 Patient
Peng et al. have outlined several characteristics common to all COVID-19 patients using lung ultrasound and the 12 zone method. Zotzmann et al. in a follow-up letter raised the question on whether these areas of subpleural... read more
Targeting MAP in Sepsis
What’s your target mean arterial pressure (MAP) for patients with sepsis? Do you believe in the magic number of 65? What about those patients with chronic hypertension? What about when there is no evidence of end organ... read more
Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19
Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more
Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO
Intracranial hemorrhage occurs early during venovenous extracorporeal membrane oxygenation (VV-ECMO) and is a determinant for 60-day mortality. Appropriate adjustment of identified modifiable risk factors might lower... read more
Effectiveness of Bundle Interventions on ICU Delirium
This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more
Mortality of Older Patients Admitted to an ICU
In this systematic review of older patients admitted to intensive care, we have documented substantial variation in short- and long-term mortality as well as in prognostic factors evaluated. To better understand this... read more
High-dose Vitamin C in Critically Ill COVID-19 Patients
This pilot trial showed that high-dose intravenous vitamin C (HDIVC) failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even... read more
Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients
The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more
