Tag: study
Pharyngeal abscess: a rare complication of repeated nasopharyngeal swabs
A 73-year-old end-stage renal disease patient who had undergone craniopharyngioma resection 30 years previously was admitted to hospital after a fall. He developed hospital-acquired laboratory-confirmed SARS-CoV-2 that required... read more
Association between perioperative fluid administration and postoperative outcomes
Irrespectively to the amount of perioperative fluid administered, goal-directed therapy (GDT) strategy reduces postoperative complications, but not perioperative mortality. The metanalysis included 21 RCTs enrolling 2,729... read more
Opioid Use After Intensive Care
Mean opioid consumption is increased 24 months after ICU admission despite the lack of evidence for long-term opioid treatment. Given the high number of ICU entries and risk of excess mortality for chronic users, preventing... read more
Association between the BMI and outcomes of patients resuscitated from OHCA
The body mass index (BMI) was not independently associated with favourable neurologic and survival outcomes of patients surviving from out-of-hospital cardiac arrest (OHCA). Nine hospitals were enrolled; finally, 605 patients... read more
Janssen Investigational COVID-19 Vaccine
An investigational COVID-19 vaccine developed by Janssen Pharmaceuticals appears to be safe and effective at preventing moderate and severe COVID-19 in adults, according to an interim analysis of Phase 3 clinical data conducted... read more
Contrast-enhanced Ultrasound (CEUS) of the Lung Reveals Multiple Areas of Microthrombi in a COVID-19 Patient
Peng et al. have outlined several characteristics common to all COVID-19 patients using lung ultrasound and the 12 zone method. Zotzmann et al. in a follow-up letter raised the question on whether these areas of subpleural... read more
Targeting MAP in Sepsis
What’s your target mean arterial pressure (MAP) for patients with sepsis? Do you believe in the magic number of 65? What about those patients with chronic hypertension? What about when there is no evidence of end organ... read more
Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19
Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more
Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO
Intracranial hemorrhage occurs early during venovenous extracorporeal membrane oxygenation (VV-ECMO) and is a determinant for 60-day mortality. Appropriate adjustment of identified modifiable risk factors might lower... read more
Effectiveness of Bundle Interventions on ICU Delirium
This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more
Mortality of Older Patients Admitted to an ICU
In this systematic review of older patients admitted to intensive care, we have documented substantial variation in short- and long-term mortality as well as in prognostic factors evaluated. To better understand this... read more
High-dose Vitamin C in Critically Ill COVID-19 Patients
This pilot trial showed that high-dose intravenous vitamin C (HDIVC) failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even... read more
Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients
The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more
Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe
In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more
ICU Strain and Mortality Risk Among Critically Ill Patients with COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has affected numerous communities, and reports of overburdened hospitals, specifically critical care units, have become commonplace. High-quality supportive care remains the... read more
Adjuvant therapeutic plasma exchange in septic shock
The hallmark of sepsis is a pathological host response to an infection that may lead to organ dysfunction, shock and high mortality. Besides numerous circulating mediators initiating inflammation, vascular barrier breakdown... read more
Serum Amylase and Lipase for the Prediction of Pancreatic Injury in Critically Ill Children Admitted to the PICU
Serum amylase and lipase could serve as independent biomarkers to predict pancreatic injury in critically ill children. A group of 79 children who died of different causes were investigated by autopsy. They were divided... read more
COVID-19: Antibody-Dependent Enhancement
The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”. And obviously, that’s the opposite of what you want. Remember that there are “neutralizing”... read more
Deep RNA Sequencing of ICU Patients with COVID-19
Current upper respiratory tract testing for COVID-19 only determines if the virus is present. Deep RNA sequencing with appropriate computational biology may provide important prognostic information and point to therapeutic... read more
The Impact of Defibrillation on Aerosol Generation During CPR
Chest compressions alone did not cause significant aerosol generation in this swine model. However, increased aerosol generation was detected during chest compression immediately following defibrillation. Additional research... read more
Why COVID-19 Pneumonia is More Deadly than Typical Pneumonia
Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or... read more
Critical Care Management of Infectious Meningitis and Encephalitis
Central nervous system (CNS) infections represent 2.9% of the infections encountered in the intensive care unit (ICU). Among them, infectious meningitis and encephalitis, regardless of their community or healthcare-associated... read more
