The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized... read more

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

Aerosolised Surfactant Trial for Preterm Infants with RDS

The AeroFact system can safely deliver aerosolised surfactant to preterm infants with respiratory distress syndrome (RDS) who are on nasal continuous positive airway pressure (nCPAP). 10 infants were enrolled in part 1... read more

Aerosolised Surfactant Trial for Preterm Infants with RDS

What the Flecainide is going on here?

A 54-year-old woman is brought to the emergency department for palpitations. In triage she has a heart rate of 120 bpm, BP 143/89, SpO2 99%. Shortly after being roomed, she begins to complain of worsening symptoms and looks... read more

What the Flecainide is going on here?

Tocilizumab Use May Be Associated with a Short-term Mortality Benefit

For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the... read more

Tocilizumab Use May Be Associated with a Short-term Mortality Benefit

COVID-19 Pathophysiology: Looking Beyond Acute Disease

Careful descriptions of the clinical features of acute disease in patients infected with the novel coronavirus SARS-CoV-2 had begun to emerge before WHO declared the outbreak of COVID-19 a public health emergency of international... read more

COVID-19 Pathophysiology: Looking Beyond Acute Disease

Tox and Hound – Metal Hydrides

We are left with four main scenarios in which arsine gas is produced and/or encountered: aqueous solutions of oxidized arsenic compounds in contact with metals metal arsenides in contact with water/moisture release... read more

Tox and Hound – Metal Hydrides

Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities

Vasopressors are commonly used in the treatment of shock to support blood pressure, cardiac output, and end-organ perfusion. These agents are associated with risk of serious adverse effects including ischemia (e.g. stroke,... read more

Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients

In a cohort of critically ill patients with a high prevalence of thromboembolic events, ET was associated with reduced ICU mortality without an increased burden of haemorrhagic complications. This study suggests ET strategies... read more

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients

Effect of Continuous Infusion of Hypertonic Saline vs. Standard Care in Patients With TBI

Among patients with moderate to severe traumatic brain injury (TBI), treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at... read more

Effect of Continuous Infusion of Hypertonic Saline vs. Standard Care in Patients With TBI

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation... read more

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Checklist for Early Recognition and Treatment of Acute Illness and Injury

A quality-improvement intervention with remote simulation training to implement a decision support tool was associated with decreased nonadherence to daily care processes, shorter length of stay, and decreased mortality. The... read more

Checklist for Early Recognition and Treatment of Acute Illness and Injury

Sepsis Subclasses: A Framework for Development and Interpretation

Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based... read more

Sepsis Subclasses: A Framework for Development and Interpretation

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

This study demonstrated the performance of the SAME device. Platelets and red blood cells were salvaged without significant impact on cell integrity and function. In the meantime, leukocytes were not activated, and the washing... read more

Combined Platelet and Erythrocyte Salvage: Evaluation of a New Filtration-based Autotransfusion Device

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Low technology, mild controlled hypothermia was feasible, not related to adverse effects, and effective treatment for NEC Modified Bell's Stage II/III. It avoided surgery, bowel perforation, and extensive intestinal resection;... read more

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Oral Midodrine Feasibility in Early Sepsis

This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more

Oral Midodrine Feasibility in Early Sepsis

Guidance on COVID-19 Clinical Care and Treatment by Specialty

We are providing these links as part of our support to members seeking specialty advice for specific medical conditions, particularly those outside their own specialty. The situation is a fast-evolving one, and while we will... read more

Guidance on COVID-19 Clinical Care and Treatment by Specialty

New Therapy Could Protect Lung Function in COVID-19 Patients

There is an urgent need for new drugs for ARDS patients, including those with COVID-19. ARDS in influenza-infected mice is associated with reduced levels of liponucleotides (essential precursors for de novo phospholipid synthesis)... read more

New Therapy Could Protect Lung Function in COVID-19 Patients