Tag: treatment
Recognition, Assessment, and Pharmacotherapeutic Treatment of Alcohol Withdrawal Syndrome in the ICU
Alcohol withdrawal syndrome (AWS) is a complex neurologic disorder that develops after an acute reduction in or cessation of chronic alcohol consumption that alters neurotransmitter conduction. The incidence of AWS in the... read more
Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence
Critical care medicine specialist Paul Marik, MD, has described himself as a status quo destabilizer, and probably nothing illustrates that designation better than the sepsis treatment known as the Marik protocol. In the... read more
Methylnaltrexone for Treatment of Opioid-induced Constipation in Critically Ill Patients
No evidence to support the addition of methylnaltrexone to regular laxatives for the treatment of opioid-induced constipation in critically ill patients; however, the confidence interval was wide and a clinically important... read more
It’s Insane to Keep Using Mortality As a Primary Endpoint in Critical Care Trials
Mortality is an important endpoint, so we shouldn't ignore mortality trends entirely. However, the vast majority of these will be spurious. Thus, we should generally not change practice due to them. In the history of critical... read more
Tranexamic Acid in TBI – CRASH-3 Trial Treatment
The CRASH-3 trial is a multi-centre, randomised, placebo-controlled trial of the effects of tranexamic acid on death and disability in patients with traumatic brain injury (TBI). Patients with reactive pupils and/or mild... read more
Clinically Significant Pleural Effusion in ICU
Clinically significant pleural effusion (PLEFF)—defined by a depth greater than or equal to 2 cm in a drainable location on thoracic ultrasound together with a potential adverse effect on patient progress—was detected... read more
Should We Treat Fever in Critically Ill Patients Without Acute Brain Pathology?
In one of the sessions at #LIVES2019 in Berlin, Prof. Frank Van Haren of Canberra Hospital, Australia, presented findings from the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management... read more
Conservative vs. Interventional Treatment for Spontaneous Pneumothorax
Although the primary outcome was not statistically robust to conservative assumptions about missing data, the trial provides modest evidence that conservative management of primary spontaneous pneumothorax was noninferior... read more
Frailty Predicts 30-day Mortality in Intensive Care Patients
Premorbid frailty was common in general ICU patients and was an independent predictor of death. Our study suggests that frailty could be a valuable addition in outcome prediction in intensive care. The receiver operating... read more
Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating
Prediction models are important in various fields, including medicine, physics, meteorology, and finance. Prediction models will become more relevant in the medical field with the increase in knowledge on potential predictors... read more
Emergency Medicine: Diagnosis and Management
Emergency Medicine: Diagnosis and Management incorporates the latest ideas and evidence base underpinning best practice emergency medicine care. This book covers a wide variety of emergencies, including general medical, critical... read more
Activin Type II Receptor Blockade for Treatment of Muscle Depletion in COPD
Blocking the action of negative muscle regulators through the activin type II receptors with bimagrumab treatment safely increased skeletal muscle mass but did not improve functional capacity in patients with COPD and low... read more
Finding a New Way to Fight Late-stage Sepsis by Boosting Cells’ Antibacterial Properties
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection. The scientists used nanotechnology... read more
Admissions Trends, Resource Use, and Risk-adjusted Hospital Mortality for Elderly Patients Admitted to ICUs
Over the past two decades, elderly patients have been more commonly admitted to ICU than can be explained solely by the demographic shift. Importantly, as with the wider population, outcomes in elderly patients admitted to... read more
Impact of a Progressive Mobility Program on the Functional Status, Respiratory and Muscular Systems of ICU Patients
Patients who participated in an ICU mobility program had better functional status at discharge from the ICU. The other benefits of the program included better performance in the mobility tests and improved maximum voluntary... read more
Improving Community Recognition of Sepsis Using Early Warning Scores
Introducing a community version of National Early Warning Score (NEWS) to clinical assessments in acute clinical care has shown benefits for both patients and staff, and could be disseminated to all community services across... read more
Time to Treatment and Mortality during Mandated Emergency Care for Sepsis
More rapid completion of a 3-hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completion of an initial bolus of intravenous fluids, were associated with lower risk-adjusted in-hospital mortality. Among... read more
