Tag: treatment
Ground-breaking Research – Venous Thrombosis is Back in Business
The primary efficacy outcome was the development of a major venous thromboembolic event such as symptomatic distal or proximal deep-vein thrombosis, asymptomatic deep vein thrombosis, pulmonary embolism or venous thromboembolism–related... read more
Inhaled Pulmonary Vasodilators
Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more
Cost Analysis of Adjunctive Hydrocortisone Therapy for Septic Shock
Using adjunctive hydrocortisone therapy yields a significant monetized benefit based on inputs from the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock and Activated Protein C and Corticosteroids... read more
Hypothermia Plus Melatonin in Asphyctic Newborns
The early addition of IV melatonin to asphyctic neonates is feasible and may improve long-term neurodevelopment. To our knowledge, this is the first clinical trial to analyze the administration of IV melatonin as an adjuvant... read more
Approach to New Fever or Rigors in the ICU Patient
Failure to recognize neutropenic fever as a separate entity that requires immediate treatment. Routinely ordering urinalysis and sputum cultures (for most patients, this will only lead to false-positive results and unnecessary... read more
Haloperidol for Treatment of Headache in the ED
Headache is a common chief complaint that emergency physicians encounter almost every day and sometimes multiple times in each shift. In fact, headache is the fifth leading cause of patients presenting to the emergency department... read more
COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies
Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... read more
Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services
This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more
Five COVID-19 Mysteries Scientists Are Still Racing to Solve
Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research... read more
The Ethics of Allocation
One of the greatest challenges in health care - and in generations - is upon us COVID-19 continues to detrimentally affect every aspect of our healthcare system. Clinicians have been faced with grim life-and-death decisions... read more
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19
Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... read more
Effect of Dexamethasone in Hospitalized Patients with COVID-19
Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... read more
Clinical Experience of Whole-body CT as the Initial Evaluation Tool After ECPR in OHCA Patients
Routine whole-body computed tomography (CT) after extracorporeal cardiopulmonary resuscitation (ECPR) in out-of-hospital cardiac arrest (OHCA) patients appears to have a limited role, as the majority is caused by ACS. However,... read more
Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients
Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more
