Renal Outcomes of Vasopressin and Its Analogs in Distributive Shock

Renal Outcomes of Vasopressin and Its Analogs in Distributive Shock

In patients with distributive shock, vasopressin and its analogs use is associated with a reduced need for renal replacement therapy and lower acute kidney injury (AKI) incidence. These results are supported by high risk... read more

Myocardial Ischemia During Ventilator Weaning

Myocardial Ischemia During Ventilator Weaning

This observational study showed the pulmonary edema (WiPO) occurred in a significant number of critically ill patients who failed a first spontaneous breathing trial (SBT), while cardiac ischemia (WiCI) was less frequent.... read more

Vasoactive Medication and Randomized Clinical Trials

Vasoactive Medication and Randomized Clinical Trials

Vasoactive medication is one of the cornerstones in the treatment of critically ill patients in shock. Shock can be defined as a failure of the circulatory system to provide adequate tissue perfusion resulting in cellular... read more

Clinical Assessment of Critically Ill Patients by Whole-body Ultrasonography

Clinical Assessment of Critically Ill Patients by Whole-body Ultrasonography

Critical care ultrasonography (CCUS) is increasingly advocated and used, and is defined as point-of-care image acquisition, interpretation and clinical application, all performed by the critical care clinician, and directed... read more

AKI in Critically Ill Patients After Noncardiac Major Surgery

AKI in Critically Ill Patients After Noncardiac Major Surgery

Acute kidney injury (AKI) is a common complication of major surgery. However, acute kidney injury occurring within the first 48 hours after surgery (early acute kidney injury) and therefore likely related to the surgery itself... read more

Early Norepinephrine Has Potential for Septic Shock

Early Norepinephrine Has Potential for Septic Shock

Standard sepsis algorithms have suggested completing a fluid bolus before starting vasopressors in patients with septic shock, but multiple observational trials have shown an association between early vasopressor use and... read more

Cardiovascular Dynamics in Critically Ill Patients

Cardiovascular Dynamics in Critically Ill Patients

Although widely used among physicians and frequently present in the literature, the words "stable" and "unstable" to describe cardiovascular dynamics in critically ill patients can have different meanings to different people... read more

More Precise Sepsis Therapy with Distinct Clinical Phenotypes

More Precise Sepsis Therapy with Distinct Clinical Phenotypes

In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may... read more

Serum Chloride Levels in Critical Illness – The Hidden Story

Serum Chloride Levels in Critical Illness – The Hidden Story

Chloride is the principal anion of the extracellular fluid and vital for both serum electroneutrality and acid-base homeostasis. The aim of this review is to investigate the relevance of dyschloremia in the critically... read more

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria

Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely... read more

Vasopressors and Inotropes for Shock Syndromes

Vasopressors and Inotropes for Shock Syndromes

Vasopressors and inotropes are cornerstones in the management of shock syndromes. Understanding vasopressors' receptor activity and resultant pharmacological response enables clinicians to select the ideal vasopressor(s)... read more

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons

Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons

Variation in the accuracy of claims data for identifying sepsis and organ dysfunction limits their use for comparing hospitals' sepsis rates and outcomes. Using objective clinical data may facilitate more meaningful hospital... read more

Pharmacotherapy in Neurointensive Care

Pharmacotherapy in Neurointensive Care

Neurointensive care medicine has experienced great advancements and developments of neuromonitoring techniques, allowing a better comprehension of acute brain injury early phase pathological mechanisms and an overall improvement... read more

Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients

Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients

In isolation of other medication, a hemodynamic response to IV acetaminophen has a higher prevalence in critically ill children with cardiac disease than previously thought and justifies controlled studies in the perioperative... read more