Diabetes Risks and Outcomes in COPD Patients
The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.... read more
Use of Wearable Devices for Post-discharge Monitoring of ICU patients
Wearable devices generate signals detecting activity, sleep, and heart rate, all of which could enable detailed and near-continuous characterization of recovery following critical illness. We found that wearable devices could... read more
iSepsis – A 30ml/kg Bolus: Yes or No -The Results
The results of both surveys are not surprising. This recommendation has never been prospectively tested in a large RCT and has little supporting evidence. Imagine the American Heart Association (AHA) or the American Diabetes... read more
Critical Illness, Disability, and the Road Home
Ability to participate in the community is an important outcome for all patients after a major illness, it signposts reaching the end of the road home. A patient's ability to return to the priority tasks of daily living impacts... read more
Faecal Transplant Effectively Treats Recurrent or Unresponsive Clostridium Difficile
Using a faecal microbiota transplant cured 92% of people with Clostridium difficile that had recurred or had not responded to antibiotics. Faecal transplant also had a lower risk of treatment failure than the antibiotic vancomycin.... read more
Implementing Clinical Practice Changes in Critical Care
Lessons learned in a national collaborative of over 60 ICU teams. Improving care in the intensive care unit (ICU) is a global area of focus for clinicians worldwide. The complexity of the ICU environment, compounded by multiple... read more
Hypoxia and Hypotension in Patients Intubated by Physician Staffed Helicopter EMS
The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators... read more
New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality
qSOFA and CRB outperformed SIRS and presented better clinical usefulness as prompt tools for patients with community-acquired pneumonia in the emergency department. Among the tools for a comprehensive patient assessment,... read more
Corticosteroid Therapy for Critically Ill Patients with the MERS
Corticosteroid therapy in patients with Middle East Respiratory Syndrome (MERS) was not associated with a difference in mortality after adjustment for time-varying confounders, but was associated with delayed MERS coronavirus... read more
Effect of Procalcitonin-guided Antibiotic Treatment on Mortality in Acute Respiratory Infections
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in... read more
50 Years of Research in ARDS
Mechanical ventilation (MV) is critical in the management of many patients with the acute respiratory distress syndrome (ARDS). However, MV can also cause ventilator-induced lung injury (VILI). The selection of an appropriate... read more
Spotlight Interview: The World of Fluids
Looking at the data from a new perspective, the article "Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill" published in Critical Care Medicine in August 2017,... read more
Health Canada Eyes Opioid Restrictions for Popular Painkiller
Health Canada has launched a review of the increasingly popular pharmaceutical drug tramadol – a move that could prompt the department to reverse its controversial, decade-old decision not to classify the medication as... read more
Challenges and Opportunities for a Precision Medicine Approach to Critical Illness
Precision medicine in critical care is a key part of our present and future. However, many challenges limit its application for all patients in the ICU. Complex acute illness among patients with multi-morbidity, integrated... read more
Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
In patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive strategy regarding red-cell transfusion was noninferior to a liberal strategy with respect to the composite outcome of death... read more
Critical Care Cycling Study (CYCLIST) Trial Protocol
Critical Care Cycling Study (CYCLIST) trial protocol: a randomised controlled trial of usual care plus additional in-bed cycling sessions versus usual care in the critically ill. In-bed cycling with patients with critical... read more
