Tag: ICU
Renal Failure and Replacement Therapies
Increased recognition of the overlap between critical care and renal medicine, and recent advances in the understanding of acute renal failure (ARF) and the application of renal replacement therapies (RRTs), have brought... read more
Early Mortality Prediction in Sepsis Patients Using Structured Features and Unstructured Clinical Notes
Sepsis is an important cause of mortality, especially in intensive care unit (ICU) patients. Developing novel methods to identify early mortality is critical for improving survival outcomes in sepsis patients. Using the... read more
Descriptors of Sepsis Using the Sepsis-3 Criteria
We successfully operationalized the Sepsis-3 criteria to an electronic health record dataset to describe the characteristics of critical care patients with sepsis. This may facilitate sepsis research using electronic health... read more
Fever is Associated with Reduced Mortality in ICU Patients with Sepsis
To evaluate the association of body temperature with mortality in septic patients admitted to the ICU from the ward. In addition, we intend to investigate whether the timing of antibiotic administration was different... read more
Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest
Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial. The latter, although a small trial, showed improved neurologic outcomes at six months when patients... read more
Inhaled Amphotericin B Lipid Complex for Prophylaxis Against COVID-19-associated Invasive Pulmonary Aspergillosis
Recently, Prattes and colleagues published in Intensive Care Medicine a high incidence of coronavirus disease 2019-associated invasive pulmonary aspergillosis (CAPA), according to 2020 ECMM/ISHAM consensus criteria, with... read more
Dynamic Prediction Tool for Mortality in COVID-19 Ventilated Patients
The COVID-19 pandemic has caused intensive care units (ICUs) to reach capacities requiring triage. A tool to predict mortality risk in ventilated patients with COVID-19 could inform decision-making and resource allocation,... read more
Novel Antibiotics Efficacy for Sepsis ICU Patients
Restricting severely ill patients access to new broad-spectrum empirical drugs is not the answer. Rather there should be a focus on identifying host response to infection to differentiate between colonization or contamination... read more
Ventilation in Patients with Intra-abdominal Hypertension
The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while one out of... read more
COVID-19: Limitation of Life-sustaining Treatment and Patient Involvement in Decision-making
Life-sustaining treatment limitation decisions were made for 18% of a COVID-19 patient cohort. Hereof, more than a third of the decisions had been made before hospital admission. Many records lacked information on patient... read more
UK 28-Day Mortality Trends of COVID-19 Patients
There was a marked deterioration in outcomes for patients admitted to critical care at the peak of the second wave of coronavirus disease 2019 in United Kingdom (December 2020–January 2021), compared with the post-first-wave... read more
The Obesity Paradox in Critically Ill Patients
A causal inference approach that is robust to residual confounding bias due to model misspecification and selection bias due to missing (at random) data mitigates the obesity paradox observed in critically ill patients, whereas... read more
Interim-analysis of the COVID-19 Patients Treated with the Seraph 100 Microbind Affinity Filter Registry
The treatment of COVID-19 patients with Seraph®100 is well tolerated and the circuit failure rate was lower than previously reported for KRT in COVID-19 patients. Mortality corelated with late initiation of Seraph treatment... read more
Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise
Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality... read more
To Bronch or Not to Bronch – That Is the Question
Percutaneous tracheostomy was safely and effectively performed by an experienced surgical team both with and without bronchoscopic guidance with no difference in the complication rates. This study suggests that the use... read more
The Importance of Accurate Glucose Monitoring in Critically Ill Patients
Critically ill patients are not found just in intensive care units, but throughout the hospital: emergency departments, post-anaesthesia care units, operating rooms, and many other environments now care for the critically... read more
Intravenous Push Levetiracetam Safety in a Neuro-Spine ICU
Administration of levetiracetam doses up to 2000 mg via IVP is a safe method of administration that results in a reduction of time to medication administration and a reduction of benzodiazepine use. Of the 2,055 hospital-wide... read more
Management of Pulmonary Embolism in the ICU
Pulmonary embolism is a reason for admission to the Intensive Care Unit and this complication in hospitalised patients is associated with high morbidity and mortality. The identification and management of pulmonary embolism... read more
First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy
Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more
Predict Sepsis-Associated Vasopressor Use in the ICU
Domain adaptation improved performance of a model predicting sepsis-associated vasopressor use during external validation. 40 retrospectively collected features from the electronic medical records of adult ICU patients... read more
Safety and Efficacy of MUST-ARDS
This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more
Rapidly Progressive Brain Atrophy in Septic ICU Patients
Many ICU patients with severe sepsis who developed prolonged mental status changes and neurological sequelae showed signs of brain atrophy. Patients with rapidly progressive brain atrophy were more likely to have required... read more
