The Intensivist’s Challenge: Aging and Career Growth in a High-Stress Medical Specialty

This book brings together personal narratives from critical care medicine specialists around the world. Most of these physicians started in critical care at or before the exponential increase in technological modalities to... read more

The Intensivist’s Challenge: Aging and Career Growth in a High-Stress Medical Specialty

Saline vs. Balanced Crystalloid in Patients with Diabetic Ketoacidosis

In patients with diabetic ketoacidosis (DKA), the use of saline may be associated with longer time to DKA resolution, higher post-resuscitation serum chloride levels, lower post-resuscitation serum bicarbonate levels, and... read more

Telemedicine in the ICU

This text provides a concise, yet comprehensive overview of telemedicine in the ICU. The first part of the book reviews common issues faced by practitioners and hospital administrators in implementing and managing tele-ICU... read more

Telemedicine in the ICU

Omicron Magnifies the Distress in the Health Care Labor System

In December 2020, to the tune of rousing cheers, the first health care workers began getting vaccinated against COVID-19. A year later, the cheers have died down, vaccination rates have plateaued, and the Omicron wave... read more

COVID-19 Guidance for Hospital Reporting and FAQs

Hospitals are responsible for reporting the information to the Federal government. Facilities should report at the individual hospital level, even if hospitals share a Centers for Medicare & Medicaid Services (CMS) Certification... read more

Bringing Biological ARDS Phenotypes to the Bedside with Machine-learning-based Classifiers

The identification of distinct phenotypes within heterogeneous disease states is a key component of personalised medicine, enabling enrichment of clinical trials, better prognostication, and delivery of tailored treatments... read more

Risk Factors for Severe COVID-19 Outcomes Among Adults Who Completed a Primary COVID-19 Vaccination

In this analysis of data from 465 U.S. health care facilities, severe COVID-19 outcomes (i.e., respiratory failure, ICU admission, or death) were rare among adults aged ≥18 years after primary vaccination. These findings... read more

Thoracic Ultrasound and Integrated Imaging

This book focuses on thoracic ultrasound, a versatile, diagnostically accurate, low-cost, noninvasive and non-ionizing imaging technique. Thanks to portable devices, the method can be used to provide quick and accurate diagnoses... read more

Thoracic Ultrasound and Integrated Imaging

Renal Failure and Replacement Therapies

Increased recognition of the overlap between critical care and renal medicine, and recent advances in the understanding of acute renal failure (ARF) and the application of renal replacement therapies (RRTs), have brought... read more

Renal Failure and Replacement Therapies

Early Mortality Prediction in Sepsis Patients Using Structured Features and Unstructured Clinical Notes

Sepsis is an important cause of mortality, especially in intensive care unit (ICU) patients. Developing novel methods to identify early mortality is critical for improving survival outcomes in sepsis patients. Using the... read more

Descriptors of Sepsis Using the Sepsis-3 Criteria

We successfully operationalized the Sepsis-3 criteria to an electronic health record dataset to describe the characteristics of critical care patients with sepsis. This may facilitate sepsis research using electronic health... read more

Fever is Associated with Reduced Mortality in ICU Patients with Sepsis

To evaluate the association of body temperature with mortality in septic patients admitted to the ICU from the ward. In addition, we intend to investigate whether the timing of antibiotic administration was different... read more

Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest

Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial. The latter, although a small trial, showed improved neurologic outcomes at six months when patients... read more

Inhaled Amphotericin B Lipid Complex for Prophylaxis Against COVID-19-associated Invasive Pulmonary Aspergillosis

Recently, Prattes and colleagues published in Intensive Care Medicine a high incidence of coronavirus disease 2019-associated invasive pulmonary aspergillosis (CAPA), according to 2020 ECMM/ISHAM consensus criteria, with... read more

Dynamic Prediction Tool for Mortality in COVID-19 Ventilated Patients

The COVID-19 pandemic has caused intensive care units (ICUs) to reach capacities requiring triage. A tool to predict mortality risk in ventilated patients with COVID-19 could inform decision-making and resource allocation,... read more

Novel Antibiotics Efficacy for Sepsis ICU Patients

Restricting severely ill patients access to new broad-spectrum empirical drugs is not the answer. Rather there should be a focus on identifying host response to infection to differentiate between colonization or contamination... read more

Ventilation in Patients with Intra-abdominal Hypertension

The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while one out of... read more

COVID-19: Limitation of Life-sustaining Treatment and Patient Involvement in Decision-making

Life-sustaining treatment limitation decisions were made for 18% of a COVID-19 patient cohort. Hereof, more than a third of the decisions had been made before hospital admission. Many records lacked information on patient... read more

UK 28-Day Mortality Trends of COVID-19 Patients

There was a marked deterioration in outcomes for patients admitted to critical care at the peak of the second wave of coronavirus disease 2019 in United Kingdom (December 2020–January 2021), compared with the post-first-wave... read more

The Obesity Paradox in Critically Ill Patients

A causal inference approach that is robust to residual confounding bias due to model misspecification and selection bias due to missing (at random) data mitigates the obesity paradox observed in critically ill patients, whereas... read more

Interim-analysis of the COVID-19 Patients Treated with the Seraph 100 Microbind Affinity Filter Registry

The treatment of COVID-19 patients with Seraph®100 is well tolerated and the circuit failure rate was lower than previously reported for KRT in COVID-19 patients. Mortality corelated with late initiation of Seraph treatment... read more

Outcome After Intubation for Septic Shock with Respiratory Distress and Hemodynamic Compromise

Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality... read more