House Officer’s Guide to ICU Care
Your Must-Have Guide for Navigating the ICU The House Officer's Guide to ICU Care is an eminently practical handbook for junior house officers, medical students, PAs, and nurses that offers nuts-and-bolts guidelines for optimal... read more
Algorithm that Detects Sepsis Cut Deaths by 18%
Hospital patients are at risk of a number of life-threatening complications, especially sepsis—a condition that can kill within hours and contributes to one out of three in-hospital deaths in the U.S. Overworked doctors... read more
Perioperative Management of Antithrombotic Therapy
Substantial new evidence has emerged since the 2012 iteration of these guidelines, especially to inform best practices for the perioperative management of patients who are receiving a VKA and may require heparin bridging,... read more
Feed Intolerance Reversal by Prokinetics Improves Survival in Critically Ill Cirrhosis Patients
Feed intolerance (FI) is common in critically-ill cirrhosis patients and non-resolution carries high mortality. Early recognition and treatment with prokinetics is recommended to improve short-term survival. Of the 1,030... read more
Current Practice Updates in Emergency Medicine
Medicine is an ever-growing specialty. With new research and trials being conducted frequently, it becomes difficult to remain updated on the subject by just reading the textbook. Moreover, the postgraduate examination also... read more
Lung and Diaphragm Protective Ventilation Guided by the Esophageal Pressure
Lung protective ventilatory strategies aim to limit tidal volume, driving pressure and plateau pressure to minimize lung stress and strain and consequently reduce the morbidity and mortality risks associated with mechanical... read more
Plasma Exchange in the ICU
In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement... read more
Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality
In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may... read more
Care Step Pathway an Effective Tool For Clinicians Caring for Mechanical Ventilated COVID-19 Patients
The Care Step Pathway (CSP) described in this article was developed to increase awareness of the potential association of SARS-CoV-2 infection with invasive fungal infections, particularly pulmonary aspergillosis. The... read more
Dexmedetomidine vs. Propofol Sedation in Critically Ill Adults Requiring Mechanical Ventilation
Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients. It also significantly... read more
Subphenotypes of AKI in Adults
Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury (AKI). Despite challenges remain, the identification of AKI subphenotypes has opened the potential of AKI research focused on better... read more
Myocarditis After COVID‐19 mRNA Vaccination in Australia
Myocarditis in adolescents and young adults following the administration of coronavirus disease 2019 (COVID‐19) mRNA vaccines has been reported. Vaccination of 12–16‐year‐old adolescents with Comirnaty (tozinameran,... read more
Surfactant Therapies for Pediatric ARDS
We advocate for well-designed preclinical and explanatory clinical studies to investigate the use of surfactant for pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome. Given the accumulating knowledge... read more
Is Continuous Intra-abdominal Pressure Ready For Prime Time?
Abdominal contents are primarily fluid in character so that pressure within this compartment follows Pascal's hydrostatic law. Intra-abdominal pressure (IAP) is the steady state pressure within the abdominal cavity and changes... read more
Improving Outcomes in Patients with Difficult Airways
Evidence indicates that the airway community has successfully conquered the anatomically difficult airway, as these patients are managed safely with a low incidence of morbidity and mortality. In contrast, the literature... read more
Protective Ventilation
As ventilator induced lung injury (VILI) importantly impacts outcome of mechanically ventilated patients, even in those without lung injury, it follows that those caring for the critically ill should apply protective ventilatory... read more
The Effect of ICU Diaries on PTSD, Anxiety, and Depression
Providing an ICU diary to patients admitted to the ICU reduced the rate of posttraumatic stress disorder (PTSD) symptoms compared with usual care. We included 7 RCTs. Patients who received a diary during the ICU admission... read more
Advanced Bleeding Control in Combat Casualty Care
Consensus was reached on the contents of a standard bleeding control toolbox, where it should be available, providers and training requirements, international registries and guidelines, and potential indications for REBOA... read more
Prone Position in Mechanically Ventilated Patients
The use of prone position (PP) during invasive mechanical ventilation was first reported more than 45 years ago as a mean to improve oxygenation in patients with acute hypoxemic respiratory failure. Improved oxygenation... read more
Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness
Whereas etomidate causes adrenal insufficiency, it was not shown to increase mortality in many analyzed here in ICU settings. However, etomidate associated relative mortality rates increased progressively and correlated with... read more
Co-infection and ICU-acquired Infection in COVID-19 ICU Patients
In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated... read more
Bedside PUG Positively Impact Efficiency and Cost Outcomes in the ICU
This study demonstrates bedside percutaneous ultrasound gastrostomy (PUG) leads to decreased Length of Stay (LOS) and total hospital costs in patients with ventilator-dependent respiratory failure. Hospital costs were significantly... read more
