Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals
Pneumonia was the leading cause of death from infectious diseases in the United States, even before the COVID-19 pandemic, and continues to be a leading cause of death. In the study, researchers at Intermountain Healthcare... read more
Sotrovimab Effect Among High-risk COVID-19 Patients
Among nonhospitalized patients with mild to moderate COVID-19 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, significantly reduced the risk of a composite end point of... read more
Critically Ill Pregnant Women with COVID-19: Management and Outcome
Coronavirus disease 2019 (COVID-19)-infected pregnant women are at higher risk of intensive care unit (ICU) admission and mechanical ventilation. Because reports describing the clinical course and management of critically... read more
Percussion Pacing – An Almost Forgotten Procedure for Hemodynamically Unstable Bradycardias?
More than 80 years after its first description by Eduard Schott, percussion (fist) pacing remains a little known procedure even though it represents an instantly available and easy to perform treatment for temporary emergency... read more
Sepsis Hospitalization and Risk of Subsequent Cardiovascular Events in Adults
Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization. 254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization... read more
Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema
This study compared the effect of placebo versus the bradykinin B2 receptor antagonist icatibant on symptoms of ACE inhibitor–associated angioedema in a mixed race population of patients. The study does not support the... read more
Buprenorphine-Precipitated Opioid Withdrawal in the ED
Buprenorphine-precipitated opioid withdrawal is seen in patients physically dependent on opioids who have recently taken full-agonist opioids and are then administered buprenorphine. Patients with severe withdrawal commonly... read more
Why Are We Still Talking about ICP and Ketamine?
A trauma patient required emergent intubation during a recent shift. The altered patient was suspected of having an intracranial bleed. My resident was concerned about rapid onset of hypoxia and other internal injuries causing... read more
Epidemiology and Outcomes of Critically Ill Children at Risk for PARDS
The Pediatric Acute Lung Injury Consensus Conference “at-risk for pediatric acute respiratory distress syndrome” criteria identify critically ill children at high risk of pediatric acute respiratory distress syndrome... read more
Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis
Participants randomized to external forced-air warming did not have a difference in HLA-DR expression or IFN-γ production. In this pilot study, however, 28-day mortality was lower in the intervention group. Future research... read more
Melatonin in ICU Delirium: Shining Light on the Hormone of Darkness
Delirium represents a form of acute brain dysfunction predictive of excess death and long-term cognitive impairment in critically ill patients. For many years, we have wondered whether pharmacological doses of melatonin would... read more
Clinical, Biological and Molecular Aspects of COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the... read more
Weaning from Ventilation and Extubation of Children in Critical Care
By reading this article, you should be able to: - Identify the predictors of successful extubation in pediatric ICU (PICU) patients. - Describe the factors affecting mechanical ventilator weaning in PICU patients. -... read more
Essentials of Shock Management: A Scenario-Based Approach
This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of... read more
Incidence of Delirium in ICU Inpatients After Cognitive Exercise Intervention
In this study, the relevant RCTs on cognitive exercise in ICU inpatients with delirium were screened for systematic evaluation and meta-analysis, aiming to explore the impact of cognitive exercises and routine nursing on... read more
Indicators for Monitoring COVID-19 Community Levels and Making Public Health Recommendations
Widespread uptake of COVID-19 vaccines that are highly effective against severe illness and death, the accrual of high rates of vaccine- and infection-induced immunity at the population level, and the availability of effective... read more
Staff Experiences Relating to Early Mobilisation of Mechanically Ventilated Patients in Intensive Care
Early mobilisation of mechanically ventilated patients has been suggested to be effective in mitigating muscle weakness, yet it is not a common practice. Understanding staff experiences is crucial to gain insights into what... read more
Resuscitation with Blood Products in Patients with Trauma-related Hemorrhagic Shock Receiving Prehospital Care
The trial did not show that prehospital PRBC–LyoPlas resuscitation was superior to 0·9% sodium chloride for adult patients with trauma related hemorrhagic shock. Further research is required to identify the characteristics... read more
Interventional Critical Care: A Manual for Advanced Care Practitioners
This book provides a comprehensive, state-of-the art review of the interventional procedures that can be performed in intensive care settings. The book addresses fundamentals of the indications and technical aspects of procedures,... read more
Balanced Crystalloids Probably Reduce Mortality in the Critically-Ill
As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more
Responding to Crisis in Ukraine
Direct Relief is working directly with Ukraine's Ministry of Health and other partners in the region to provide requested medical aid, from oxygen concentrators to critical care medicines – while preparing to offer longer-term... read more
Balanced vs. Unbalanced Fluid in Critically Ill Children
Our systematic review found some evidence of improvement in blood pH and bicarbonate values in critically ill children after 4–12 hours of fluid bolus therapy with balanced fluid compared with the unbalanced fluid. However,... read more
