Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage

Reduced glucose variability is highly correlated with in-patient survival and long-term mortality in subarachnoid hemorrhage (aSAH) patients. This finding was observed in the non-diabetic and well-controlled diabetic patients,... read more

Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage

Global, Regional, and National Sepsis Incidence and Mortality: 1990-2017

Globally, there were an estimated 60.2 million cases of sepsis in 1990 and 48.9 million cases of sepsis in 2017. This change represents a decrease of 18.8%. Of all incident cases of sepsis in 2017, 33.1 million occurred... read more

Global, Regional, and National Sepsis Incidence and Mortality: 1990-2017

AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU

Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... read more

AKI Epidemiology, Risk factors, and Outcomes in Critically Ill Patients 16-25 Years of Age Treated in an Adult ICU

Beta-Blocker Therapy in Severe TBI

Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more

Beta-Blocker Therapy in Severe TBI

Neuroprognostication Practices in Postcardiac Arrest Patients

Neuroprognostic approaches to hypoxic-ischemic encephalopathy vary among physicians and are often not consistent with current guidelines. The overall inconsistency in approaches and deviation from evidence-based recommendations... read more

Neuroprognostication Practices in Postcardiac Arrest Patients

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality) compared with standard-issue red blood... read more

Blood Transfusion – Fresh vs. Standard-issue in Critically Ill Pediatric Patients

Frailty Predicts 30-day Mortality in Intensive Care Patients

Premorbid frailty was common in general ICU patients and was an independent predictor of death. Our study suggests that frailty could be a valuable addition in outcome prediction in intensive care. The receiver operating... read more

Frailty Predicts 30-day Mortality in Intensive Care Patients

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

In this study of mechanically ventilated patients, 31% of study participants had acute respiratory distress syndrome (ARDS) at some point during their ICU stay. Optimal lung-protective ventilation was not used in a majority... read more

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

Maternal Risk Modeling in Critical Care

Risk prediction models specific to the maternal critical care population was developed. The models compare favorably against general adult ICU risk prediction models in current use within this population. The aim was to... read more

Maternal Risk Modeling in Critical Care

Impact of Levosimendan on Weaning from Peripheral VA-ECMO in ICU

This study suggests that levosimendan might be associated with a beneficial effect on venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning in ICU patients. The difference in mortality among propensity-matched... read more

Impact of Levosimendan on Weaning from Peripheral VA-ECMO in ICU

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Patients with isolated traumatic brain injury (TBI) are likely to benefit from effective prehospital care to prevent secondary brain injury. Only a few studies have focused on the impact of advanced interventions in TBI... read more

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Sepsis Kills Twice as Many People as Experts Feared

Sepsis, which is triggered by an infection, is the cause of 1 in 5 deaths worldwide. It is thought to have killed 47,860 in 2017 - ranking us 45th worst out of 195 countries. Researchers estimate the condition claimed... read more

Sepsis Kills Twice as Many People as Experts Feared

Study Suggests Benefits of Vitamin C for Severe Sepsis

More than 1.7 million Americans develop sepsis every year and incidence of the condition is on the rise. In severe cases, widespread inflammation leads to multiorgan failure and death. Results of a new study hold... read more

Study Suggests Benefits of Vitamin C for Severe Sepsis

Is Intensive Care Becoming an Out-of-hours Acute Palliative Care Service?

First I will define what I conceive medicine to be. In general terms, it is to do away with the sufferings of the sick, to lessen the violence of their diseases, and to refuse to treat those who are overmastered by their... read more

Is Intensive Care Becoming an Out-of-hours Acute Palliative Care Service?

Lower Glucose Targets Show Improved Mortality in Cardiac Patients

Tighter glucose control while minimizing the risk of severe hypoglycemia is associated with lower mortality among critically ill cardiac patents, new research suggests. Researchers reported in CHEST on the outcomes of... read more

Lower Glucose Targets Show Improved Mortality in Cardiac Patients

Serum Lactate Level and Mortality in Metformin-associated Lactic Acidosis Requiring RRT

This study suggests that predialysis level of serum lactate level is an important marker of mortality in MALA patients requiring renal replacement therapy (RRT) with a linear dose-response relationship. To better evaluate... read more

Serum Lactate Level and Mortality in Metformin-associated Lactic Acidosis Requiring RRT

Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus Aureus Bacteremia

The results of this study further support the importance of prompt appropriate antibiotic administration for patients with septic shock. Physicians should consider acting quickly to administer antibiotics with S. aureus... read more

Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus Aureus Bacteremia

ICU Bouncebacks Associated with Worse Outcomes

ICU Bouncebacks (ICUBBs) are associated with worse outcomes and are disproportionately burdened by respiratory complications. These findings emphasize the importance of the TQIP Collaborative in identifying statewide... read more

ICU Bouncebacks Associated with Worse Outcomes