Case-Based Device Therapy for Heart Failure
This book provides a comprehensive practical guide to the plethora of devices that have been developed to support the failing heart. It features easy to follow clinically relevant guidance on mechanical devices used for improving... read more
Predicting Sepsis Severity at First Clinical Presentation
The severity and endotype signatures indicate that distinct immune signatures precede the onset of severe sepsis and lethality, providing a method to triage early sepsis patients. Gene expression signatures were obtained... read more
Advanced Hemodynamic Monitoring: Basics and New Horizons
This book describes how to monitor and optimize cardiovascular dynamics using advanced hemodynamic monitoring in perioperative and intensive care medicine. The book outlines basic skills of hemodynamic monitoring, different... read more
Resuscitation Using ECPR During In-Hospital Cardiac Arrest Mortality Prediction Score
The RESCUE-IHCA score can be used by clinicians in real time to predict in-hospital death among patients with in-hospital cardiac arrest (IHCA) who are treated with extracorporeal cardiopulmonary resuscitation (ECPR). A... read more
Intravenous Vitamin C Administration to Septic Shock Patients
Our pilot study indicated that intravenous vitamin C did not provide significant decreases in the mean dose or duration of vasopressor infusion. Further research that takes into account the potential impact of intervention... read more
Physics for Anesthesiologists and Intensivists: From Daily Life to Clinical Practice
This book, now in its 2nd edition, discusses, explains and provides detailed, up-to-date information on physics applied to clinical practice in anesthesiology and critical care medicine, with the aid of simple examples from... read more
Physiologically Difficult Airway Evaluation
Multiple international airway societies have created guidelines for the management of the difficult airway. In critically ill patients, there are physiologic derangements beyond inadequate airway protection or hypoxemia.... read more
ARDS Subphenotypes Validation and Utility Identified by Machine-learning Models
Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies... read more
Long-term Cardiovascular Outcomes of COVID-19
The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used... read more
Coupled Plasma Filtration and Adsorption for Septic Shock Treatment
Early deaths are likely related to the ongoing CPFA treatment, for reasons that if identified could allow some deaths to be prevented. We hypothesize a connection to hemodynamic instability consequent on renal replacement... read more
Guidelines on Temperature Control After Cardiac Arrest in Adults
The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are coma‑tose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying... read more
Fluid Balance and Ventilator-Associated Events Among Patients Admitted to ICUs in China
There was nonlinear relationship between fluid balance and all three tiers of ventilator-associated event, with an fluid balance between –1 and 0 L corresponding to the lowest risk. Positive but not negative fluid balance... read more
Impact of Frailty on Persistent Critical Illness
Compared to patients without frailty, those with frailty have a higher chance of developing and dying from Persistent Critical Illness (PerCI). Moreover the importance of frailty as a predictor of mortality increases with... read more
Equipotent Ratios for the Most Common Vasopressors
Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more
ICU Quick Drug Guide
Offering essential, evidence-based practice guidelines specifically for the critical care setting, ICU Quick Drug Guide contains up-to-date information in a quick-access format. This portable handbook provides fast, accurate... read more
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more
Critical COVID-19 Pneumonia Determinants
SARS-CoV-2 infection is benign in most individuals but, in approx. 10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years... read more
The Reemergence of Ketamine for Treatment in Critically Ill Adults
Ketamine has suggested potential benefit in several disease states impacting critically ill patients including pain, alcohol withdrawal syndrome, status epilepticus, and acute agitation. Further supporting evidence is needed... read more
COVID-19 Vaccine: Safety and Efficacy
Two doses of SCB-2019 vaccine plus CpG and alum provides notable protection against the entire severity spectrum of COVID-19 caused by circulating SAR-CoV-2 viruses, including the predominating delta variant. This ongoing... read more
Assessment of Patiromer Monotherapy for Hyperkalemia in an Acute Care Setting
In this cohort study of patients with acute, non–life-threatening hyperkalemia, a single dose of patiromer was associated with a significant decrease in serum potassium levels and a low incidence of hypokalemia. These... read more
COVID-19 Mortality Prediction Model
While there have been extensive analyses characterizing cellular and humoral responses across the severity spectrum in COVID-19, predictors of outcomes within severe COVID-19 remain to be comprehensively elucidated. Recently,... read more
The Ongoing Saga of Normal Saline vs. Balanced Fluids
I have discussed the ongoing battle between normal saline and ‘balanced fluids’ many times in the past. First, there was the SPLIT trial, a double blind cluster RCT of 2200 ICU patients that showed no difference between... read more
