Tag: research
Subphenotypes of AKI in Adults
Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury (AKI). Despite challenges remain, the identification of AKI subphenotypes has opened the potential of AKI research focused on better... read more
Myocarditis After COVID‐19 mRNA Vaccination in Australia
Myocarditis in adolescents and young adults following the administration of coronavirus disease 2019 (COVID‐19) mRNA vaccines has been reported. Vaccination of 12–16‐year‐old adolescents with Comirnaty (tozinameran,... read more
Mental Health Morbidity Among Caregivers
While much of the research on post-ICU mental health morbidity has focused upon the survivors themselves, emerging data shows that caregivers of ICU patients are similarly impacted. The collective sequelae experienced... read more
Public Sepsis Awareness Campaigns Should Be Created Based on Local Data
Although public knowledge of sepsis and its mortality is generally low, some countries have high awareness and knowledge, and as such, any public awareness campaigns should be created based on local data. This will also... read more
Intravenous Tenecteplase vs. Alteplase for Acute Ischemic Stroke
Between Dec 10, 2019, and Jan 25, 2022, 1,600 patients were enrolled and randomly assigned to tenecteplase (n=816) or alteplase (n=784), of whom 1577 were included in the intention-to-treat (ITT) population (n=806 tenecteplase;... read more
Benchmarking Saliency Methods for Chest X-ray Interpretation
Saliency methods, which "explain" deep neural networks by producing heat maps that highlight the areas of the medical image that influence model prediction, are often presented to clinicians as an aid in diagnostic decision-making.... read more
Medical Nutrition Therapy and Clinical Outcomes in Critically Ill Adults
Calorie intake was mainly provided according to the targets recommended by the active ESPEN guideline, but protein intake was lower. In patients staying in ICU ≥ 5 days, early moderate daily calorie and protein intakes... read more
Hydroxychloroquine Not Associated With Decreased Risk for COVID-19 Hospitalization
Results of a multicenter, double-blinded, randomized controlled trial found no evidence to support the use of hydroxychloroquine for COVID-19 infection in the outpatient setting. These findings were published in The Lancet... read more
Patients Monitored Using Wearable Monitors Experienced Fewer Unplanned ICU Admissions
Implementation of continuous monitoring of patient vital signs using wearable monitoring technology linked wirelessly to hospital systems was associated with a reduction in unplanned ICU admissions and rapid response team... read more
Standardized Data Collection in Prehospital Critical Care
The medical problems categorized by HEMS personnel can be seen as valid. The greatest challenges remain in the classification of stroke and other neurological emergencies. Patients treated by HEMS personnel are characterized... read more
ARDS Readmissions: A nationwide Cross-sectional Analysis of Epidemiology
Thirty-day readmission occurred in 18.4% of patients with acute respiratory distress syndrome (ARDS) in this sample, and early readmission is strongly associated with increased mortality compared to late readmission. Further... read more
Casemix, management, and mortality of patients receiving emergency neurosurgery for TBI
Patients receiving emergency neurosurgery for traumatic brain injury (TBI) differed considerably in their admission characteristics and management across human development settings. Level of human development was associated... read more
Obstructive Airway Diseases: Role of Lipid Mediators
Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is... read more
Electronic Pneumonia Decision Support Helps Reduce Mortality by 38% in Community Hospitals
Pneumonia was the leading cause of death from infectious diseases in the United States, even before the COVID-19 pandemic, and continues to be a leading cause of death. In the study, researchers at Intermountain Healthcare... read more
Percussion Pacing – An Almost Forgotten Procedure for Hemodynamically Unstable Bradycardias?
More than 80 years after its first description by Eduard Schott, percussion (fist) pacing remains a little known procedure even though it represents an instantly available and easy to perform treatment for temporary emergency... read more
Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis
Participants randomized to external forced-air warming did not have a difference in HLA-DR expression or IFN-γ production. In this pilot study, however, 28-day mortality was lower in the intervention group. Future research... read more
Resuscitation with Blood Products in Patients with Trauma-related Hemorrhagic Shock Receiving Prehospital Care
The trial did not show that prehospital PRBC–LyoPlas resuscitation was superior to 0·9% sodium chloride for adult patients with trauma related hemorrhagic shock. Further research is required to identify the characteristics... read more
Pediatric Pneumonia Research Priorities in the Context of COVID-19
Operational research on health system capacities, and evaluating optimized delivery of existing treatments, diagnostics and case management approaches are needed. This list should act as a catalyst for collaborative research,... read more
Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes
This book discusses the evidence behind the relationship between COVID-19 and heart disease based on emerging state-of-the-art data. The rapid and unexpected global spread of the COVID-19 has revealed proportional levels... read more
Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia
Advances in perinatal care have dramatically improved survival of extremely preterm infants and the incidence of bronchopulmonary dysplasia (BPD) has not changed over the past few decades, which likely reflects the impact... read more
Immunotherapy
The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types... read more
Antiviral Drug Discovery and Development
This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced... read more
